We propose a three-year Interdisciplinary Biology Initiative (IBI) at the Kavli Institute for Theoretical Physics KITP) that will consist of a series of extended programs ranging thematically from Systems Biology, Bioinformatics and Genomics, to Neuroscience and Biophysics. We propose to hold 2 programs per year, each ranging from 4 to 12 weeks in duration. The long term goal of this initiative is to foster interactions between physical and mathematical scientists, computer scientists and engineers with life scientists, and to establish an interdisciplinary community focused on the development of new quantitative approaches to the study of important biological and biomedical problems. With its established role in the physics community,
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