Abstract

The planned studies will be a continuation of ongoing projects that reflect a long interest in abnormal growth regulation in the human hematopoietic system. 1. Combined chromosomal and molecular studies, with Dr. Carlo Croce and others, of specific genes involved in human lymphoid and myeloid neoplasms and mechanisms leading to altered gene function. 2. Longitudinal cytogenetic studies in chronic B cell and T cell disorders correlated with clinical, biological, and immunological characteristics of these neoplasms. 3. Further investigation of altered growth regulation in chronic B cell and T cell disorders, including inhibitory factors (transforming growth factor-beta), stimulatory factors, and the role of autoreactivity in B-CLL. (This grant is a component of the University of Pennsylvania Cancer Center)

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Unknown (R35)
Project #
5R35CA042232-12
Application #
2376798
Study Section
Special Emphasis Panel (SRC (88))
Project Start
1986-05-10
Project End
2000-02-29
Budget Start
1997-03-21
Budget End
1998-02-28
Support Year
12
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
University of Pennsylvania
Department
Pathology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Zhang, Qian; Capocasale, Renold J; Fox, Floyd E et al. (2002) Diminished expression of the type II receptor for TGFbeta (TGFbetaRII) in T lymphocytes from patients with Sezary syndrome is not due to mutations in the receptor's poly-A tract: limitations of the standard RT-PCR in cDNA sequence analysis of homopolymeri Arch Immunol Ther Exp (Warsz) 50:421-9
Zaki, M; Douglas, R; Patten, N et al. (2000) Disruption of the IFN-gamma cytokine network in chronic lymphocytic leukemia contributes to resistance of leukemic B cells to apoptosis. Leuk Res 24:611-21
Engels, F H; Koski, G K; Bedrosian, I et al. (1999) Calcium signaling induces acquisition of dendritic cell characteristics in chronic myelogenous leukemia myeloid progenitor cells. Proc Natl Acad Sci U S A 96:10332-7
Edwards, R H; Wasik, M A; Finan, J et al. (1999) Evidence for early hematopoietic progenitor cell involvement in acute promyelocytic leukemia. Am J Clin Pathol 112:819-27
Besa, E C; Kunselman, S; Nowell, P C (1998) A pilot trial of 13-cis-retinoic acid and alpha-tocopherol with recombinant human erythropoietin in myelodysplastic syndrome patients with progressive or transfusion-dependent anemias. The Central Pennsylvania Oncology Group. Leuk Res 22:741-9
Felix, C A; Hosler, M R; Slater, D J et al. (1998) MLL genomic breakpoint distribution within the breakpoint cluster region in de novo leukemia in children. J Pediatr Hematol Oncol 20:299-308
Liang, H; Fairman, J; Claxton, D F et al. (1998) Molecular anatomy of chromosome 7q deletions in myeloid neoplasms: evidence for multiple critical loci. Proc Natl Acad Sci U S A 95:3781-5
Megonigal, M D; Rappaport, E F; Nowell, P C et al. (1998) Potential role for wild-type p53 in leukemias with MLL gene translocations. Oncogene 16:1351-6
Felix, C A; Walker, A H; Lange, B J et al. (1998) Association of CYP3A4 genotype with treatment-related leukemia. Proc Natl Acad Sci U S A 95:13176-81
Douglas, R S; Pletcher Jr, C H; Nowell, P C et al. (1998) Novel approach for simultaneous evaluation of cell phenotype, apoptosis, and cell cycle using multiparameter flow cytometry. Cytometry 32:57-65

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