Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Unknown (R35)
Project #
3R35CA042508-06S1
Application #
3479331
Study Section
Special Emphasis Panel (SRC)
Project Start
1986-06-01
Project End
1992-05-31
Budget Start
1991-06-01
Budget End
1992-05-31
Support Year
6
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Shabat, D; Lode, H N; Pertl, U et al. (2001) In vivo activity in a catalytic antibody-prodrug system: Antibody catalyzed etoposide prodrug activation for selective chemotherapy. Proc Natl Acad Sci U S A 98:7528-33
Xiang, R; Silletti, S; Lode, H N et al. (2001) Protective immunity against human carcinoembryonic antigen (CEA) induced by an oral DNA vaccine in CEA-transgenic mice. Clin Cancer Res 7:856s-864s
Lode, H N; Reisfeld, R A (2000) Targeted cytokines for cancer immunotherapy. Immunol Res 21:279-88
Xiang, R; Lode, H N; Chao, T H et al. (2000) An autologous oral DNA vaccine protects against murine melanoma. Proc Natl Acad Sci U S A 97:5492-7
Lode, H N; Xiang, R; Pertl, U et al. (2000) Melanoma immunotherapy by targeted IL-2 depends on CD4(+) T-cell help mediated by CD40/CD40L interaction. J Clin Invest 105:1623-30
Balicki, D; Reisfeld, R A; Pertl, U et al. (2000) Histone H2A-mediated transient cytokine gene delivery induces efficient antitumor responses in murine neuroblastoma. Proc Natl Acad Sci U S A 97:11500-4
Lode, H N; Pertl, U; Xiang, R et al. (2000) Tyrosine hydroxylase-based DNA-vaccination is effective against murine neuroblastoma. Med Pediatr Oncol 35:641-6
Lode, H N; Xiang, R; Duncan, S R et al. (1999) Tumor-targeted IL-2 amplifies T cell-mediated immune response induced by gene therapy with single-chain IL-12. Proc Natl Acad Sci U S A 96:8591-6
Lode, H N; Moehler, T; Xiang, R et al. (1999) Synergy between an antiangiogenic integrin alphav antagonist and an antibody-cytokine fusion protein eradicates spontaneous tumor metastases. Proc Natl Acad Sci U S A 96:1591-6
Nayeem, N; Silletti, S; Yang, X et al. (1999) A potential role for the plasmin(ogen) system in the posttranslational cleavage of the neural cell adhesion molecule L1. J Cell Sci 112 ( Pt 24):4739-49

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