Abstract

Specific Aims: l) To elucidate the developmental decisions enacted by hematopoietic stem cells that lead to self-renewal, lineage commitment, and in lymphocytes, antigen receptor diversity. 2) To define cellular interactions and developmental decisions that occur during normal and neoplastic thymic lymphocyte maturation. 3) To study the role of cell surface homing receptors on normal lymphocyte homing and inflammation, and in malignant cell metastasis. 4) To study the events in mouse, pre-B leukemogenesis that results in abnormal proliferation and invasiveness; and to study the role of the 6C3/BPl metalloprotease in murine and human lymphoid neoplasms. 5) To continue to study a protochordate (Botryllus schlosseri) model for the evolution and function of allorecognition, including the genes that encode allorecognition behavior; and to develop genetic stocks and the laboratory mariculture techniques to make this unique invertebrate/vertebrate available to the scientific community.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Unknown (R35)
Project #
5R35CA042551-13
Application #
2712602
Study Section
Special Emphasis Panel (SRC (88))
Program Officer
Mccarthy, Susan A
Project Start
1986-08-01
Project End
2000-05-31
Budget Start
1998-06-12
Budget End
1999-05-31
Support Year
13
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
Stanford University
Department
Pathology
Type
Schools of Medicine
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305

  Publications

Cheshier, Samuel H; Prohaska, Susan S; Weissman, Irving L (2007) The effect of bleeding on hematopoietic stem cell cycling and self-renewal. Stem Cells Dev 16:707-17
Allsopp, Richard C; Morin, Gregg B; DePinho, Ronald et al. (2003) Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation. Blood 102:517-20
Allsopp, Richard C; Morin, Gregg B; Horner, James W et al. (2003) Effect of TERT over-expression on the long-term transplantation capacity of hematopoietic stem cells. Nat Med 9:369-71
Chadwick-Furman, Nanette E; Weissman, Irving L (2003) Effects of allogeneic contact on life-history traits of the colonial ascidian Botryllus schlosseri in Monterey Bay. Biol Bull 205:133-43
Jaiswal, Siddhartha; Traver, David; Miyamoto, Toshihiro et al. (2003) Expression of BCR/ABL and BCL-2 in myeloid progenitors leads to myeloid leukemias. Proc Natl Acad Sci U S A 100:10002-7
Nakorn, Thanyaphong Na; Miyamoto, Toshihiro; Weissman, Irving L (2003) Characterization of mouse clonogenic megakaryocyte progenitors. Proc Natl Acad Sci U S A 100:205-10
Domen, Jos; Weissman, Irving L (2003) Hematopoietic stem cells and other hematopoietic cells show broad resistance to chemotherapeutic agents in vivo when overexpressing bcl-2. Exp Hematol 31:631-9
King, Angela G; Kondo, Motonari; Scherer, David C et al. (2002) Lineage infidelity in myeloid cells with TCR gene rearrangement: a latent developmental potential of proT cells revealed by ectopic cytokine receptor signaling. Proc Natl Acad Sci U S A 99:4508-13
Allsopp, Richard C; Cheshier, Samuel; Weissman, Irving L (2002) Telomerase activation and rejuvenation of telomere length in stimulated T cells derived from serially transplanted hematopoietic stem cells. J Exp Med 196:1427-33
Na Nakorn, Thanyaphong; Traver, David; Weissman, Irving L et al. (2002) Myeloerythroid-restricted progenitors are sufficient to confer radioprotection and provide the majority of day 8 CFU-S. J Clin Invest 109:1579-85

Showing the most recent 10 out of 103 publications