Abstract

The major areas of research include development of new methods for long range cloning gene enrichment, isolation of DNA protein complexes and rapid detection and isolation of cis and trans elements involved in the regulation of the cell type and host range specificity of viral DNA replication and transcription. These and related approaches will be applied to analysis of gene regulation in the SV40 system and in the expression of proteins of immunologic importance as well as in an analysis of the control of development of various T cell subsets.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Unknown (R35)
Project #
5R35CA042556-04
Application #
3479397
Study Section
(SRC)
Project Start
1986-06-01
Project End
1993-05-31
Budget Start
1989-06-01
Budget End
1990-05-31
Support Year
4
Fiscal Year
1989
Total Cost
Indirect Cost

  Institution

Name
Yale University
Department
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520

  Publications

Lian, Zheng; Kluger, Yuval; Greenbaum, Dov S et al. (2002) Genomic and proteomic analysis of the myeloid differentiation program: global analysis of gene expression during induced differentiation in the MPRO cell line. Blood 100:3209-20
Horak, Christine E; Mahajan, Milind C; Luscombe, Nicholas M et al. (2002) GATA-1 binding sites mapped in the beta-globin locus by using mammalian chIp-chip analysis. Proc Natl Acad Sci U S A 99:2924-9
Mahajan, Milind C; Weissman, Sherman M (2002) DNA-dependent adenosine triphosphatase (helicaselike transcription factor) activates beta-globin transcription in K562 cells. Blood 99:348-56
Lian, Z; Wang, L; Yamaga, S et al. (2001) Genomic and proteomic analysis of the myeloid differentiation program. Blood 98:513-24
Raghunathan, A; Sivakamasundari, R; Wolenski, J et al. (2001) Functional analysis of B144/LST1: a gene in the tumor necrosis factor cluster that induces formation of long filopodia in eukaryotic cells. Exp Cell Res 268:230-44
Nakayama, Y; Weissman, S M; Bothwell, A L (2001) BXMAS1 identifies a cluster of homologous genes differentially expressed in B cells. Biochem Biophys Res Commun 285:830-7
Subrahmanyam, Y V; Yamaga, S; Prashar, Y et al. (2001) RNA expression patterns change dramatically in human neutrophils exposed to bacteria. Blood 97:2457-68
Yang, Y H; Chen, Y H; Zhang, C Y et al. (2000) Cloning and characterization of two mouse genes with homology to the yeast Sir2 gene. Genomics 69:355-69
Hisama, F M; Chen, Y H; Meyn, M S et al. (2000) WRN or telomerase constructs reverse 4-nitroquinoline 1-oxide sensitivity in transformed Werner syndrome fibroblasts. Cancer Res 60:2372-6
Sivakamasundari, R; Raghunathan, A; Zhang, C Y et al. (2000) Expression and cellular localization of the protein encoded by the 1C7 gene: a recently described component of the MHC. Immunogenetics 51:723-32

Showing the most recent 10 out of 42 publications