Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
4R37AG004542-17
Application #
6654771
Study Section
Special Emphasis Panel (NSS)
Program Officer
Wise, Bradley C
Project Start
1998-01-01
Project End
2008-02-28
Budget Start
2003-03-01
Budget End
2004-02-29
Support Year
17
Fiscal Year
2003
Total Cost
$367,202
Indirect Cost
Name
University of Kentucky
Department
Pharmacology
Type
Schools of Medicine
DUNS #
939017877
City
Lexington
State
KY
Country
United States
Zip Code
40506
Gant, John C; Blalock, Eric M; Chen, Kuey-Chu et al. (2018) FK506-Binding Protein 12.6/1b, a Negative Regulator of [Ca2+], Rescues Memory and Restores Genomic Regulation in the Hippocampus of Aging Rats. J Neurosci 38:1030-1041
Gant, John C; Kadish, Inga; Chen, Kuey-Chu et al. (2018) Aging-Related Calcium Dysregulation in Rat Entorhinal Neurons Homologous with the Human Entorhinal Neurons in which Alzheimer's Disease Neurofibrillary Tangles First Appear. J Alzheimers Dis 66:1371-1378
Frazier, Hilaree N; Maimaiti, Shaniya; Anderson, Katie L et al. (2017) Calcium's role as nuanced modulator of cellular physiology in the brain. Biochem Biophys Res Commun 483:981-987
Alzheimer's Association Calcium Hypothesis Workgroup (2017) Calcium Hypothesis of Alzheimer's disease and brain aging: A framework for integrating new evidence into a comprehensive theory of pathogenesis. Alzheimers Dement 13:178-182.e17
Gant, John C; Chen, Kuey-Chu; Kadish, Inga et al. (2015) Reversal of Aging-Related Neuronal Ca2+ Dysregulation and Cognitive Impairment by Delivery of a Transgene Encoding FK506-Binding Protein 12.6/1b to the Hippocampus. J Neurosci 35:10878-87
Latimer, Caitlin S; Brewer, Lawrence D; Searcy, James L et al. (2014) Vitamin D prevents cognitive decline and enhances hippocampal synaptic function in aging rats. Proc Natl Acad Sci U S A 111:E4359-66
Gant, J C; Blalock, E M; Chen, K-C et al. (2014) FK506-binding protein 1b/12.6: a key to aging-related hippocampal Ca2+ dysregulation? Eur J Pharmacol 739:74-82
Thibault, Olivier; Anderson, Katie L; DeMoll, Chris et al. (2013) Hippocampal calcium dysregulation at the nexus of diabetes and brain aging. Eur J Pharmacol 719:34-43
Pancani, Tristano; Anderson, Katie L; Brewer, Lawrence D et al. (2013) Effect of high-fat diet on metabolic indices, cognition, and neuronal physiology in aging F344 rats. Neurobiol Aging 34:1977-87
Thibault, Olivier; Pancani, Tristano; Landfield, Philip W et al. (2012) Reduction in neuronal L-type calcium channel activity in a double knock-in mouse model of Alzheimer's disease. Biochim Biophys Acta 1822:546-9

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