Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
2R37AI022931-15
Application #
6094575
Study Section
Bacteriology and Mycology Subcommittee 2 (BM)
Project Start
1989-07-01
Project End
2005-03-31
Budget Start
2000-04-01
Budget End
2001-03-31
Support Year
15
Fiscal Year
2000
Total Cost
$376,000
Indirect Cost

  Institution

Name
University of California Irvine
Department
Pathology
Type
Schools of Medicine
DUNS #
161202122
City
Irvine
State
CA
Country
United States
Zip Code
92697

  Publications

Schaal, Justin B; Maretzky, Thorsten; Tran, Dat Q et al. (2018) Macrocyclic ?-defensins suppress tumor necrosis factor-? (TNF-?) shedding by inhibition of TNF-?-converting enzyme. J Biol Chem 293:2725-2734
Basso, Virginia; Garcia, Angie; Tran, Dat Q et al. (2018) Fungicidal Potency and Mechanisms of ?-Defensins against Multidrug-Resistant Candida Species. Antimicrob Agents Chemother 62:
Oh, Young Taek; Tran, Dat; Buchanan, Thomas A et al. (2015) ?-Defensin RTD-1 improves insulin action and normalizes plasma glucose and FFA levels in diet-induced obese rats. Am J Physiol Endocrinol Metab 309:E154-60
Tai, Kenneth P; Kamdar, Karishma; Yamaki, Jason et al. (2015) Microbicidal effects of ?- and ?-defensins against antibiotic-resistant Staphylococcus aureus and Pseudomonas aeruginosa. Innate Immun 21:17-29
Tongaonkar, Prasad; Trinh, Katie K; Schaal, Justin B et al. (2015) Rhesus macaque ?-defensin RTD-1 inhibits proinflammatory cytokine secretion and gene expression by inhibiting the activation of NF-?B and MAPK pathways. J Leukoc Biol 98:1061-70
Mastroianni, Jennifer R; Lu, Wuyuan; Selsted, Michael E et al. (2014) Differential Susceptibility of Bacteria to Mouse Paneth Cell ?-Defensins under Anaerobic Conditions. Antibiotics (Basel) 3:493-508
Tai, Kenneth P; Le, Valerie V; Selsted, Michael E et al. (2014) Hydrophobic determinants of ?-defensin bactericidal activity. Infect Immun 82:2195-202
Schaal, Justin B; Tran, Dat; Tran, Patti et al. (2012) Rhesus macaque theta defensins suppress inflammatory cytokines and enhance survival in mouse models of bacteremic sepsis. PLoS One 7:e51337
Tongaonkar, Prasad; Golji, Amir E; Tran, Patti et al. (2012) High fidelity processing and activation of the human ?-defensin HNP1 precursor by neutrophil elastase and proteinase 3. PLoS One 7:e32469
Mastroianni, Jennifer R; Costales, Jessica K; Zaksheske, Jennifer et al. (2012) Alternative luminal activation mechanisms for paneth cell ?-defensins. J Biol Chem 287:11205-12

Showing the most recent 10 out of 84 publications