Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37AI029619-07
Application #
2065108
Study Section
Bacteriology and Mycology Subcommittee 2 (BM)
Project Start
1990-04-01
Project End
2000-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
7
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Portnoy, Daniel A (2005) Manipulation of innate immunity by bacterial pathogens. Curr Opin Immunol 17:25-8
Cheng, Luisa W; Viala, Julie P M; Stuurman, Nico et al. (2005) Use of RNA interference in Drosophila S2 cells to identify host pathways controlling compartmentalization of an intracellular pathogen. Proc Natl Acad Sci U S A 102:13646-51
Brockstedt, Dirk G; Giedlin, Martin A; Leong, Meredith L et al. (2004) Listeria-based cancer vaccines that segregate immunogenicity from toxicity. Proc Natl Acad Sci U S A 101:13832-7
Bakardjiev, Anna I; Stacy, Brian A; Fisher, Susan J et al. (2004) Listeriosis in the pregnant guinea pig: a model of vertical transmission. Infect Immun 72:489-97
McCaffrey, Ramona L; Fawcett, Paul; O'Riordan, Mary et al. (2004) A specific gene expression program triggered by Gram-positive bacteria in the cytosol. Proc Natl Acad Sci U S A 101:11386-91
Lenz, Laurel L; Mohammadi, Sina; Geissler, Aimee et al. (2003) SecA2-dependent secretion of autolytic enzymes promotes Listeria monocytogenes pathogenesis. Proc Natl Acad Sci U S A 100:12432-7
Cheng, Luisa W; Portnoy, Daniel A (2003) Drosophila S2 cells: an alternative infection model for Listeria monocytogenes. Cell Microbiol 5:875-85
Auerbuch, Victoria; Loureiro, Joseph J; Gertler, Frank B et al. (2003) Ena/VASP proteins contribute to Listeria monocytogenes pathogenesis by controlling temporal and spatial persistence of bacterial actin-based motility. Mol Microbiol 49:1361-75
O'Riordan, Mary; Moors, Marlena A; Portnoy, Daniel A (2003) Listeria intracellular growth and virulence require host-derived lipoic acid. Science 302:462-4
Glomski, Ian J; Decatur, Amy L; Portnoy, Daniel A (2003) Listeria monocytogenes mutants that fail to compartmentalize listerolysin O activity are cytotoxic, avirulent, and unable to evade host extracellular defenses. Infect Immun 71:6754-65

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