Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
3R37AR019622-18S1
Application #
2078431
Study Section
Physiological Chemistry Study Section (PC)
Project Start
1977-08-15
Project End
1995-07-31
Budget Start
1994-08-01
Budget End
1995-07-31
Support Year
18
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of Chicago
Department
Pediatrics
Type
Schools of Medicine
DUNS #
225410919
City
Chicago
State
IL
Country
United States
Zip Code
60637
Domowicz, Miriam S; Mueller, Melissa M; Novak, Todd E et al. (2003) Developmental expression of the HNK-1 carbohydrate epitope on aggrecan during chondrogenesis. Dev Dyn 226:42-50
Schwartz, Nancy B; Domowicz, Miriam (2002) Chondrodysplasias due to proteoglycan defects. Glycobiology 12:57R-68R
Pirok 3rd, E W; Henry, J; Schwartz, N B (2001) cis elements that control the expression of chick aggrecan. J Biol Chem 276:16894-903
Domowicz, M S; Pirok 3rd, E W; Novak, T E et al. (2000) Role of the C-terminal G3 domain in sorting and secretion of aggrecan core protein and ubiquitin-mediated degradation of accumulated mutant precursors. J Biol Chem 275:35098-105
Schwartz, N (2000) Biosynthesis and regulation of expression of proteoglycans. Front Biosci 5:D649-55
Krueger Jr, R C; Kurima, K; Schwartz, N B (1999) Completion of the mouse aggrecan gene structure and identification of the defect in the cmd-Bc mouse as a near complete deletion of the murine aggrecan gene. Mamm Genome 10:1119-25
Kurima, K; Singh, B; Schwartz, N B (1999) Genomic organization of the mouse and human genes encoding the ATP sulfurylase/adenosine 5'-phosphosulfate kinase isoform SK2. J Biol Chem 274:33306-12
Immergluck, L C; Domowicz, M S; Schwartz, N B et al. (1998) Viral and cellular requirements for entry of herpes simplex virus type 1 into primary neuronal cells. J Gen Virol 79 ( Pt 3):549-59
Schwartz, N B; Lyle, S; Ozeran, J D et al. (1998) Sulfate activation and transport in mammals: system components and mechanisms. Chem Biol Interact 109:143-51
Pirok 3rd, E W; Li, H; Mensch Jr, J R et al. (1997) Structural and functional analysis of the chick chondroitin sulfate proteoglycan (aggrecan) promoter and enhancer region. J Biol Chem 272:11566-74

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