Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
3R37AR032961-14S1
Application #
2410824
Study Section
Biophysical Chemistry Study Section (BBCB)
Project Start
1983-12-01
Project End
1998-11-30
Budget Start
1996-12-01
Budget End
1997-11-30
Support Year
14
Fiscal Year
1997
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Biochemistry
Type
Schools of Medicine
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Muretta, Joseph M; Reddy, Babu J N; Scarabelli, Guido et al. (2018) A posttranslational modification of the mitotic kinesin Eg5 that enhances its mechanochemical coupling and alters its mitotic function. Proc Natl Acad Sci U S A 115:E1779-E1788
Elam, W Austin; Cao, Wenxiang; Kang, Hyeran et al. (2017) Phosphomimetic S3D cofilin binds but only weakly severs actin filaments. J Biol Chem 292:19565-19579
Guhathakurta, Piyali; Prochniewicz, Ewa; Roopnarine, Osha et al. (2017) A Cardiomyopathy Mutation in the Myosin Essential Light Chain Alters Actomyosin Structure. Biophys J 113:91-100
Colson, Brett A; Thompson, Andrew R; Espinoza-Fonseca, L Michel et al. (2016) Site-directed spectroscopy of cardiac myosin-binding protein C reveals effects of phosphorylation on protein structural dynamics. Proc Natl Acad Sci U S A 113:3233-8
Espinoza-Fonseca, L Michel; Alamo, Lorenzo; Pinto, Antonio et al. (2015) Sequential myosin phosphorylation activates tarantula thick filament via a disorder-order transition. Mol Biosyst 11:2167-79
Guhathakurta, Piyali; Prochniewicz, Ewa; Thomas, David D (2015) Amplitude of the actomyosin power stroke depends strongly on the isoform of the myosin essential light chain. Proc Natl Acad Sci U S A 112:4660-5
Alamo, Lorenzo; Li, Xiaochuan Edward; Espinoza-Fonseca, L Michel et al. (2015) Tarantula myosin free head regulatory light chain phosphorylation stiffens N-terminal extension, releasing it and blocking its docking back. Mol Biosyst 11:2180-9
Muretta, Joseph M; Rohde, John A; Johnsrud, Daniel O et al. (2015) Direct real-time detection of the structural and biochemical events in the myosin power stroke. Proc Natl Acad Sci U S A 112:14272-7
Muretta, Joseph M; Jun, Yonggun; Gross, Steven P et al. (2015) The structural kinetics of switch-1 and the neck linker explain the functions of kinesin-1 and Eg5. Proc Natl Acad Sci U S A 112:E6606-13
Binder, Benjamin P; Cornea, Sinziana; Thompson, Andrew R et al. (2015) High-resolution helix orientation in actin-bound myosin determined with a bifunctional spin label. Proc Natl Acad Sci U S A 112:7972-7

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