Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37CA018138-28
Application #
6632971
Study Section
Special Emphasis Panel (NSS)
Program Officer
Gallahan, Daniel L
Project Start
1975-12-01
Project End
2005-04-30
Budget Start
2003-05-01
Budget End
2004-04-30
Support Year
28
Fiscal Year
2003
Total Cost
$346,275
Indirect Cost
Name
Pennsylvania State University
Department
Physiology
Type
Schools of Medicine
DUNS #
129348186
City
Hershey
State
PA
Country
United States
Zip Code
17033
Nowotarski, Shannon L; Feith, David J; Shantz, Lisa M (2015) Skin Carcinogenesis Studies Using Mouse Models with Altered Polyamines. Cancer Growth Metastasis 8:17-27
Shi, Chenxu; Cooper, Timothy K; McCloskey, Diane E et al. (2012) S-adenosylmethionine decarboxylase overexpression inhibits mouse skin tumor promotion. Carcinogenesis 33:1310-8
Giordano, Emanuele; Hillary, Rebecca A; Vary, Thomas C et al. (2012) Overexpression of ornithine decarboxylase decreases ventricular systolic function during induction of cardiac hypertrophy. Amino Acids 42:507-518
Welsh, Patricia A; Sass-Kuhn, Suzanne; Prakashagowda, Chethana et al. (2012) Spermine synthase overexpression in vivo does not increase susceptibility to DMBA/TPA skin carcinogenesis or Min-Apc intestinal tumorigenesis. Cancer Biol Ther 13:358-68
Shi, Chenxu; Welsh, Patricia A; Sass-Kuhn, Suzanne et al. (2012) Characterization of transgenic mice with overexpression of spermidine synthase. Amino Acids 42:495-505
Pegg, Anthony E (2011) Multifaceted roles of alkyltransferase and related proteins in DNA repair, DNA damage, resistance to chemotherapy, and research tools. Chem Res Toxicol 24:618-39
Pegg, Anthony E; Casero Jr, Robert A (2011) Current status of the polyamine research field. Methods Mol Biol 720:3-35
Bale, Shridhar; Baba, Kavita; McCloskey, Diane E et al. (2010) Complexes of Thermotoga maritimaS-adenosylmethionine decarboxylase provide insights into substrate specificity. Acta Crystallogr D Biol Crystallogr 66:181-9
Pegg, Anthony E; Michael, Anthony J (2010) Spermine synthase. Cell Mol Life Sci 67:113-21
Pegg, Anthony E; Wang, Xiaojing (2009) Mouse models to investigate the function of spermine. Commun Integr Biol 2:271-4

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