Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37CA053394-06
Application #
2095313
Study Section
Virology Study Section (VR)
Project Start
1994-02-07
Project End
1998-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
6
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of California Davis
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
094878337
City
Davis
State
CA
Country
United States
Zip Code
95618

  Publications

Rosen, Meghan D; Chan, Ivan H; Privalsky, Martin L (2011) Mutant thyroid hormone receptors (TRs) isolated from distinct cancer types display distinct target gene specificities: a unique regulatory repertoire associated with two renal clear cell carcinomas. Mol Endocrinol 25:1311-25
Chan, Ivan H; Privalsky, Martin L (2010) A conserved lysine in the thyroid hormone receptor-alpha1 DNA-binding domain, mutated in hepatocellular carcinoma, serves as a sensor for transcriptional regulation. Mol Cancer Res 8:15-23
Rosen, Meghan D; Privalsky, Martin L (2009) Thyroid hormone receptor mutations found in renal clear cell carcinomas alter corepressor release and reveal helix 12 as key determinant of corepressor specificity. Mol Endocrinol 23:1183-92
Chan, Ivan H; Privalsky, Martin L (2009) Isoform-specific transcriptional activity of overlapping target genes that respond to thyroid hormone receptors alpha1 and beta1. Mol Endocrinol 23:1758-75
Chan, I H; Privalsky, M L (2009) Thyroid hormone receptor mutants implicated in human hepatocellular carcinoma display an altered target gene repertoire. Oncogene 28:4162-74
Chan, I H; Privalsky, M L (2006) Thyroid hormone receptors mutated in liver cancer function as distorted antimorphs. Oncogene 25:3576-88
Lee, Sangho; Privalsky, Martin L (2005) Heterodimers of retinoic acid receptors and thyroid hormone receptors display unique combinatorial regulatory properties. Mol Endocrinol 19:863-78
Lee, Sangho; Privalsky, Martin L (2005) Multiple mutations contribute to repression by the v-Erb A oncoprotein. Oncogene 24:6737-52
Hayakawa, Fumihiko; Privalsky, Martin L (2004) Phosphorylation of PML by mitogen-activated protein kinases plays a key role in arsenic trioxide-mediated apoptosis. Cancer Cell 5:389-401
Yang, Z; Privalsky, M L (2001) Isoform-specific transcriptional regulation by thyroid hormone receptors: hormone-independent activation operates through a steroid receptor mode of co-activator interaction. Mol Endocrinol 15:1170-85

Showing the most recent 10 out of 38 publications