Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
3R37DA006214-14S1
Application #
6799119
Study Section
Integrative, Functional and Cognitive Neuroscience 8 (IFCN)
Program Officer
Volman, Susan
Project Start
1992-08-01
Project End
2008-04-30
Budget Start
2003-05-01
Budget End
2004-04-30
Support Year
14
Fiscal Year
2003
Total Cost
$46,448
Indirect Cost
Name
University of Pennsylvania
Department
Psychiatry
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Moorman, David E; James, Morgan H; Kilroy, Elisabeth A et al. (2017) Orexin/hypocretin-1 receptor antagonism reduces ethanol self-administration and reinstatement selectively in highly-motivated rats. Brain Res 1654:34-42
Porter-Stransky, Kirsten A; Bentzley, Brandon S; Aston-Jones, Gary (2017) Individual differences in orexin-I receptor modulation of motivation for the opioid remifentanil. Addict Biol 22:303-317
Bentzley, Brandon S; Aston-Jones, Gary (2017) Inhibiting subthalamic nucleus decreases cocaine demand and relapse: therapeutic potential. Addict Biol 22:946-957
James, Morgan H; Aston-Jones, Gary (2017) Orexin/Hypocretin, Central Amygdala, and Escalation of Cocaine Intake. Biol Psychiatry 81:552-553
Lopez, Marcelo F; Moorman, David E; Aston-Jones, Gary et al. (2016) The highly selective orexin/hypocretin 1 receptor antagonist GSK1059865 potently reduces ethanol drinking in ethanol dependent mice. Brain Res 1636:74-80
McGlinchey, Ellen M; James, Morgan H; Mahler, Stephen V et al. (2016) Prelimbic to Accumbens Core Pathway Is Recruited in a Dopamine-Dependent Manner to Drive Cued Reinstatement of Cocaine Seeking. J Neurosci 36:8700-11
Moorman, David E; James, Morgan H; Kilroy, Elisabeth A et al. (2016) Orexin/hypocretin neuron activation is correlated with alcohol seeking and preference in a topographically specific manner. Eur J Neurosci 43:710-20
Moorman, David E; Aston-Jones, Gary (2015) Prefrontal neurons encode context-based response execution and inhibition in reward seeking and extinction. Proc Natl Acad Sci U S A 112:9472-7
Kaufling, Jennifer; Aston-Jones, Gary (2015) Persistent Adaptations in Afferents to Ventral Tegmental Dopamine Neurons after Opiate Withdrawal. J Neurosci 35:10290-303
Bentzley, Brandon S; Aston-Jones, Gary (2015) Orexin-1 receptor signaling increases motivation for cocaine-associated cues. Eur J Neurosci 41:1149-56

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