Abstract

This is an application for a Research Supplement to Promote Diversity in Health-Related Research (PA-18-586). The Parent R37 Project associated with this application is entitled ?Post- translational Regulation of Opioid and Cannabinoid Receptors? supported by NIDA (R37DA08863-23). Seshat Mack is the diversity candidate. She is a US citizen of African- American descent and is currently an MD/PhD graduate student at Icahn School of Medicine at Mount Sinai, New York. The main goal of this study is the characterization of a newly deorphanized striatal neuropeptide receptor involved in modulating rewarding behaviors.

Public Health Relevance

These studies are likely to open new avenues of research relating to neuroendocrine regulation of reward- related disorders. In addition to providing essential information about signaling by this novel neuropeptide- receptor system, these studies describe compounds with great research and/or therapeutic potential.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
3R37DA008863-24S1
Application #
9698691
Study Section
Program Officer
Wu, Da-Yu
Project Start
1995-03-15
Project End
2022-03-31
Budget Start
2018-06-01
Budget End
2019-03-31
Support Year
24
Fiscal Year
2018
Total Cost
Indirect Cost

  Institution

Name
Icahn School of Medicine at Mount Sinai
Department
Pharmacology
Type
Schools of Medicine
DUNS #
078861598
City
New York
State
NY
Country
United States
Zip Code
10029

  Publications

Heimann, Andrea S; Gupta, Achla; Gomes, Ivone et al. (2018) Correction: Generation of G protein-coupled receptor antibodies differentially sensitive to conformational states. PLoS One 13:e0193322
Fricker, Lloyd D; Devi, Lakshmi A (2018) Orphan neuropeptides and receptors: Novel therapeutic targets. Pharmacol Ther 185:26-33
Lueptow, Lindsay M; Devi, Lakshmi A; Fakira, Amanda K (2018) Targeting the Recently Deorphanized Receptor GPR83 for the Treatment of Immunological, Neuroendocrine and Neuropsychiatric Disorders. Prog Mol Biol Transl Sci 159:1-25
Margolis, Elyssa B; Fujita, Wakako; Devi, Lakshmi A et al. (2017) Two delta opioid receptor subtypes are functional in single ventral tegmental area neurons, and can interact with the mu opioid receptor. Neuropharmacology 123:420-432
Reckziegel, Patrícia; Festuccia, William T; Britto, Luiz R G et al. (2017) A novel peptide that improves metabolic parameters without adverse central nervous system effects. Sci Rep 7:14781
Heimann, Andrea S; Gupta, Achla; Gomes, Ivone et al. (2017) Generation of G protein-coupled receptor antibodies differentially sensitive to conformational states. PLoS One 12:e0187306
Bobeck, Erin N; Gomes, Ivone; Pena, Darlene et al. (2017) The BigLEN-GPR171 Peptide Receptor System Within the Basolateral Amygdala Regulates Anxiety-Like Behavior and Contextual Fear Conditioning. Neuropsychopharmacology 42:2527-2536
Gomes, Ivone; Sierra, Salvador; Devi, Lakshmi A (2016) Detection of Receptor Heteromerization Using In Situ Proximity Ligation Assay. Curr Protoc Pharmacol 75:2.16.1-2.16.31
Gomes, Ivone; Bobeck, Erin N; Margolis, Elyssa B et al. (2016) Identification of GPR83 as the receptor for the neuroendocrine peptide PEN. Sci Signal 9:ra43
Wardman, Jonathan H; Gomes, Ivone; Bobeck, Erin N et al. (2016) Identification of a small-molecule ligand that activates the neuropeptide receptor GPR171 and increases food intake. Sci Signal 9:ra55

Showing the most recent 10 out of 57 publications