Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37DK009171-43
Application #
7118084
Study Section
Special Emphasis Panel (NSS)
Program Officer
Sechi, Salvatore
Project Start
1994-10-01
Project End
2007-08-31
Budget Start
2006-09-01
Budget End
2007-08-31
Support Year
43
Fiscal Year
2006
Total Cost
$466,558
Indirect Cost

  Institution

Name
University of California Santa Barbara
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
094878394
City
Santa Barbara
State
CA
Country
United States
Zip Code
93106

  Publications

Zhang, Xiaodong; Bruice, Thomas C (2008) Mechanism of product specificity of AdoMet methylation catalyzed by lysine methyltransferases: transcriptional factor p53 methylation by histone lysine methyltransferase SET7/9. Biochemistry 47:2743-8
Park, Myunji; Canzio, Daniele; Bruice, Thomas C (2008) Incorporation of positively charged ribonucleic guanidine linkages into oligodeoxyribonucleotides: Development of potent antisense agents. Bioorg Med Chem Lett 18:2377-84
Zhang, Xiaodong; Bruice, Thomas C (2007) Histone lysine methyltransferase SET7/9: formation of a water channel precedes each methyl transfer. Biochemistry 46:14838-44
Zhang, Xiaodong; Reddy, Swarnalatha Y; Bruice, Thomas C (2007) Mechanism of methanol oxidation by quinoprotein methanol dehydrogenase. Proc Natl Acad Sci U S A 104:745-9
Zhang, Xiaodong; Bruice, Thomas C (2007) Catalytic mechanism and product specificity of rubisco large subunit methyltransferase: QM/MM and MD investigations. Biochemistry 46:5505-14
Luo, Jia; Bruice, Thomas C (2007) Low-frequency normal modes in horse liver alcohol dehydrogenase and motions of residues involved in the enzymatic reaction. Biophys Chem 126:80-5
Toporowski, Joseph W; Reddy, Swarnalatha Y; Bruice, Thomas C (2007) An investigation of the ionic and solvation patterns of dsDNG versus dsDNA by use of molecular dynamics simulations. Biophys Chem 126:132-9
Zhang, Xiaodong; Bruice, Thomas C (2007) A quantum mechanics/molecular mechanics study of the catalytic mechanism and product specificity of viral histone lysine methyltransferase. Biochemistry 46:9743-51
Zhang, Xiaodong; Bruice, Thomas C (2006) The mechanism of M.HhaI DNA C5 cytosine methyltransferase enzyme: a quantum mechanics/molecular mechanics approach. Proc Natl Acad Sci U S A 103:6148-53
Correa, Bryan J; Canzio, Daniele; Kahane, Alexandra L et al. (2006) DNA sequence recognition by Hoechst 33258 conjugates of hairpin pyrrole/imidazole polyamides. Bioorg Med Chem Lett 16:3745-50

Showing the most recent 10 out of 43 publications