Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
4R37DK018243-29
Application #
6727963
Study Section
Special Emphasis Panel (NSS)
Program Officer
Laughlin, Maren R
Project Start
1978-06-01
Project End
2008-06-30
Budget Start
2003-08-01
Budget End
2004-06-30
Support Year
29
Fiscal Year
2003
Total Cost
$693,283
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Physiology
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Yu, Erin Nz; Winnick, Jason J; Edgerton, Dale S et al. (2016) Hepatic and Whole-Body Insulin Metabolism during Proestrus and Estrus in Mongrel Dogs. Comp Med 66:235-40
Rivera, Noelia; Ramnanan, Christopher J; An, Zhibo et al. (2010) Insulin-induced hypoglycemia increases hepatic sensitivity to glucagon in dogs. J Clin Invest 120:4425-35
Edgerton, Dale S; Basu, Rita; Ramnanan, Christopher J et al. (2010) Effect of 11 beta-hydroxysteroid dehydrogenase-1 inhibition on hepatic glucose metabolism in the conscious dog. Am J Physiol Endocrinol Metab 298:E1019-26
Ramnanan, Christopher J; Edgerton, Dale S; Rivera, Noelia et al. (2010) Molecular characterization of insulin-mediated suppression of hepatic glucose production in vivo. Diabetes 59:1302-11
Ramnanan, Christopher J; Edgerton, Dale S; Cherrington, Alan D (2009) The role of CCK8 in the inhibition of glucose production. Cellscience 6:92-97
Edgerton, Dale S; Ramnanan, Christopher J; Grueter, Carrie A et al. (2009) Effects of insulin on the metabolic control of hepatic gluconeogenesis in vivo. Diabetes 58:2766-75
Nelson, Robert H; Edgerton, Dale S; Basu, Rita et al. (2007) Triglyceride uptake and lipoprotein lipase-generated fatty acid spillover in the splanchnic bed of dogs. Diabetes 56:1850-5
Cherrington, A D; Moore, M C; Sindelar, D K et al. (2007) Insulin action on the liver in vivo. Biochem Soc Trans 35:1171-4
Edgerton, Dale S; Lautz, Margaret; Scott, Melanie et al. (2006) Insulin's direct effects on the liver dominate the control of hepatic glucose production. J Clin Invest 116:521-7
Everett-Grueter, Carrie; Edgerton, Dale S; Donahue, E Patrick et al. (2006) The effect of an acute elevation of NEFA concentrations on glucagon-stimulated hepatic glucose output. Am J Physiol Endocrinol Metab 291:E449-59

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