Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37DK035107-21
Application #
6777536
Study Section
Special Emphasis Panel (NSS)
Program Officer
Laughlin, Maren R
Project Start
1984-07-01
Project End
2007-06-30
Budget Start
2004-07-01
Budget End
2005-06-30
Support Year
21
Fiscal Year
2004
Total Cost
$885,153
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Physiology
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Hall, Robert K; Wang, Xiaohui L; George, Leena et al. (2007) Insulin represses phosphoenolpyruvate carboxykinase gene transcription by causing the rapid disruption of an active transcription complex: a potential epigenetic effect. Mol Endocrinol 21:550-63
Herzog, Birger; Cardenas, Jessica; Hall, Robert K et al. (2006) Estrogen-related receptor alpha is a repressor of phosphoenolpyruvate carboxykinase gene transcription. J Biol Chem 281:99-106
Herzog, Birger; Hall, Robert K; Wang, Xiaohui L et al. (2004) Peroxisome proliferator-activated receptor gamma coactivator-1alpha, as a transcription amplifier, is not essential for basal and hormone-induced phosphoenolpyruvate carboxykinase gene expression. Mol Endocrinol 18:807-19
Wang, Xiaohui L; Herzog, Birger; Waltner-Law, Mary et al. (2004) The synergistic effect of dexamethasone and all-trans-retinoic acid on hepatic phosphoenolpyruvate carboxykinase gene expression involves the coactivator p300. J Biol Chem 279:34191-200
Waltner-Law, Mary; Duong, David T; Daniels, Marc C et al. (2003) Elements of the glucocorticoid and retinoic acid response units are involved in cAMP-mediated expression of the PEPCK gene. J Biol Chem 278:10427-35
Duong, David T; Waltner-Law, Mary E; Sears, Rosalie et al. (2002) Insulin inhibits hepatocellular glucose production by utilizing liver-enriched transcriptional inhibitory protein to disrupt the association of CREB-binding protein and RNA polymerase II with the phosphoenolpyruvate carboxykinase gene promoter. J Biol Chem 277:32234-42
Waltner-Law, Mary E; Wang, Xiaohui L; Law, Brian K et al. (2002) Epigallocatechin gallate, a constituent of green tea, represses hepatic glucose production. J Biol Chem 277:34933-40
Cusi, K J; Pratipanawatr, T; Koval, J et al. (2001) Exercise increases hexokinase II mRNA, but not activity in obesity and type 2 diabetes. Metabolism 50:602-6
Stafford, J M; Waltner-Law, M; Granner, D K (2001) Role of accessory factors and steroid receptor coactivator 1 in the regulation of phosphoenolpyruvate carboxykinase gene transcription by glucocorticoids. J Biol Chem 276:3811-9
Stafford, J M; Wilkinson, J C; Beechem, J M et al. (2001) Accessory factors facilitate the binding of glucocorticoid receptor to the phosphoenolpyruvate carboxykinase gene promoter. J Biol Chem 276:39885-91

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