Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
2R37DK038682-10
Application #
2140620
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1987-05-01
Project End
1999-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Washington University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Young, Margaret A; Larson, David E; Sun, Chiao-Wang et al. (2012) Background mutations in parental cells account for most of the genetic heterogeneity of induced pluripotent stem cells. Cell Stem Cell 10:570-82
Lu, Zhi Hong; Books, Jason T; Ley, Timothy J (2006) Cold shock domain family members YB-1 and MSY4 share essential functions during murine embryogenesis. Mol Cell Biol 26:8410-7
Lu, Zhi Hong; Books, Jason T; Ley, Timothy J (2005) YB-1 is important for late-stage embryonic development, optimal cellular stress responses, and the prevention of premature senescence. Mol Cell Biol 25:4625-37
Lu, Zhi Hong; Books, Jason T; Kaufman, Richard M et al. (2003) Long targeting arms do not increase the efficiency of homologous recombination in the beta-globin locus of murine embryonic stem cells. Blood 102:1531-3
Kaufman, R M; Lu, Z H; Behl, R et al. (2001) Lack of neighborhood effects from a transcriptionally active phosphoglycerate kinase-neo cassette located between the murine beta-major and beta-minor globin genes. Blood 98:65-73
Kaufman, R M; Pham, C T; Ley, T J (1999) Transgenic analysis of a 100-kb human beta-globin cluster-containing DNA fragment propagated as a bacterial artificial chromosome. Blood 94:3178-84
Graubert, T A; Hug, B A; Wesselschmidt, R et al. (1998) Stochastic, stage-specific mechanisms account for the variegation of a human globin transgene. Nucleic Acids Res 26:2849-58
Ley, T J; Hug, B; Fiering, S et al. (1998) Reduced beta-globin gene expression in adult mice containing deletions of locus control region 5' HS-2 or 5' HS-3. Ann N Y Acad Sci 850:45-53
Hug, B A; Wesselschmidt, R L; Fiering, S et al. (1996) Analysis of mice containing a targeted deletion of beta-globin locus control region 5' hypersensitive site 3. Mol Cell Biol 16:2906-12
Graubert, T A; Russell, J H; Ley, T J (1996) The role of granzyme B in murine models of acute graft-versus-host disease and graft rejection. Blood 87:1232-7

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