Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
3R37EY005127-12S1
Application #
2159306
Study Section
Visual Sciences A Study Section (VISA)
Project Start
1983-05-01
Project End
1995-06-30
Budget Start
1994-07-01
Budget End
1995-06-30
Support Year
12
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Massachusetts Institute of Technology
Department
Physics
Type
Schools of Arts and Sciences
DUNS #
City
Cambridge
State
MA
Country
United States
Zip Code
02139
Wang, Ying; Lomakin, Aleksey; McManus, Jennifer J et al. (2010) Phase behavior of mixtures of human lens proteins Gamma D and Beta B1. Proc Natl Acad Sci U S A 107:13282-7
McManus, Jennifer J; Lomakin, Aleksey; Ogun, Olutayo et al. (2007) Altered phase diagram due to a single point mutation in human gammaD-crystallin. Proc Natl Acad Sci U S A 104:16856-61
Lomakin, A; Teplow, D B; Kirschner, D A et al. (1997) Kinetic theory of fibrillogenesis of amyloid beta-protein. Proc Natl Acad Sci U S A 94:7942-7
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Lomakin, A; Chung, D S; Benedek, G B et al. (1996) On the nucleation and growth of amyloid beta-protein fibrils: detection of nuclei and quantitation of rate constants. Proc Natl Acad Sci U S A 93:1125-9
Pande, J; Ogun, O; Nath, C et al. (1993) Suppression of phase separation in bovine gamma IV crystallin solutions: effect of modification by charged versus uncharged polar groups. Exp Eye Res 57:257-64
Siezen, R J; Coppin, C M; Kaplan, E D et al. (1989) Oxidative modifications to crystallins induced in calf lenses in vitro by hydrogen peroxide. Exp Eye Res 48:225-35
Siezen, R J; Hom, C; Kaplan, E D et al. (1988) Heterogeneity of gamma-crystallins from spiny dogfish (Squalus acanthias) eye lens. Exp Eye Res 46:81-93
Siezen, R J; Wu, E; Kaplan, E D et al. (1988) Rat lens gamma-crystallins. Characterization of the six gene products and their spatial and temporal distribution resulting from differential synthesis. J Mol Biol 199:475-90
Clark, J I; Carper, D (1987) Phase separation in lens cytoplasm is genetically linked to cataract formation in the Philly mouse. Proc Natl Acad Sci U S A 84:122-5

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