Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
3R37GM020194-20S1
Application #
3484351
Study Section
Metallobiochemistry Study Section (BMT)
Project Start
1975-06-01
Project End
1997-06-30
Budget Start
1992-07-01
Budget End
1993-06-30
Support Year
20
Fiscal Year
1993
Total Cost
Indirect Cost
Name
University of New Hampshire
Department
Type
Schools of Engineering
DUNS #
111089470
City
Durham
State
NH
Country
United States
Zip Code
03824
Mathies, Guinevere; Gast, Peter; Chasteen, N Dennis et al. (2015) Exploring the Fe(III) binding sites of human serum transferrin with EPR at 275 GHz. J Biol Inorg Chem 20:487-96
Steere, Ashley N; Chasteen, N Dennis; Miller, Brendan F et al. (2012) Structure-based mutagenesis reveals critical residues in the transferrin receptor participating in the mechanism of pH-induced release of iron from human serum transferrin. Biochemistry 51:2113-21
Steere, Ashley N; Miller, Brendan F; Roberts, Samantha E et al. (2012) Ionic residues of human serum transferrin affect binding to the transferrin receptor and iron release. Biochemistry 51:686-94
Steere, Ashley N; Byrne, Shaina L; Chasteen, N Dennis et al. (2010) Evidence that His349 acts as a pH-inducible switch to accelerate receptor-mediated iron release from the C-lobe of human transferrin. J Biol Inorg Chem 15:1341-52
Steere, Ashley N; Roberts, Samantha E; Byrne, Shaina L et al. (2010) Properties of a homogeneous C-lobe prepared by introduction of a TEV cleavage site between the lobes of human transferrin. Protein Expr Purif 72:32-41
Byrne, Shaina L; Chasteen, N Dennis; Steere, Ashley N et al. (2010) The unique kinetics of iron release from transferrin: the role of receptor, lobe-lobe interactions, and salt at endosomal pH. J Mol Biol 396:130-40
Byrne, Shaina L; Steere, Ashley N; Chasteen, N Dennis et al. (2010) Identification of a kinetically significant anion binding (KISAB) site in the N-lobe of human serum transferrin. Biochemistry 49:4200-7
Mason, Anne B; Byrne, Shaina L; Everse, Stephen J et al. (2009) A loop in the N-lobe of human serum transferrin is critical for binding to the transferrin receptor as revealed by mutagenesis, isothermal titration calorimetry, and epitope mapping. J Mol Recognit 22:521-9
Mason, Anne B; Halbrooks, Peter J; James, Nicholas G et al. (2009) Structural and functional consequences of the substitution of glycine 65 with arginine in the N-lobe of human transferrin. Biochemistry 48:1945-53
Bou-Abdallah, Fadi; Biasiotto, Giorgio; Arosio, Paolo et al. (2004) The putative ""nucleation site"" in human H-chain ferritin is not required for mineralization of the iron core. Biochemistry 43:4332-7

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