Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
4R37GM024908-19
Application #
2174355
Study Section
Special Emphasis Panel (NSS)
Project Start
1978-04-01
Project End
2001-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
19
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Biochemistry
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Koutmos, Markos; Gherasim, Carmen; Smith, Janet L et al. (2011) Structural basis of multifunctionality in a vitamin B12-processing enzyme. J Biol Chem 286:29780-7
Matthews, Rowena G (2009) Cobalamin- and corrinoid-dependent enzymes. Met Ions Life Sci 6:53-114
Huang, Sha; Romanchuk, Gail; Pattridge, Katherine et al. (2007) Reactivation of methionine synthase from Thermotoga maritima (TM0268) requires the downstream gene product TM0269. Protein Sci 16:1588-95
Yamada, Kazuhiro; Strahler, John R; Andrews, Philip C et al. (2005) Regulation of human methylenetetrahydrofolate reductase by phosphorylation. Proc Natl Acad Sci U S A 102:10454-9
Evans, John C; Huddler, Donald P; Hilgers, Mark T et al. (2004) Structures of the N-terminal modules imply large domain motions during catalysis by methionine synthase. Proc Natl Acad Sci U S A 101:3729-36
Bandarian, Vahe; Matthews, Rowena G (2004) Measurement of energetics of conformational change in cobalamin-dependent methionine synthase. Methods Enzymol 380:152-69
Hondorp, Elise R; Matthews, Rowena G (2004) Oxidative stress inactivates cobalamin-independent methionine synthase (MetE) in Escherichia coli. PLoS Biol 2:e336
Bandarian, Vahe; Ludwig, Martha L; Matthews, Rowena G (2003) Factors modulating conformational equilibria in large modular proteins: a case study with cobalamin-dependent methionine synthase. Proc Natl Acad Sci U S A 100:8156-63
Kacprzak, Magdalena M; Lewandowska, Irmina; Matthews, Rowena G et al. (2003) Transcriptional regulation of methionine synthase by homocysteine and choline in Aspergillus nidulans. Biochem J 376:517-24
Dorweiler, Jeanne Sirovatka; Finke, Richard G; Matthews, Rowena G (2003) Cobalamin-dependent methionine synthase: probing the role of the axial base in catalysis of methyl transfer between methyltetrahydrofolate and exogenous cob(I)alamin or cob(I)inamide. Biochemistry 42:14653-62

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