Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
3R37GM029048-22S1
Application #
6646135
Study Section
Special Emphasis Panel (NSS)
Program Officer
Flicker, Paula F
Project Start
1981-04-01
Project End
2006-03-31
Budget Start
2002-04-01
Budget End
2003-03-31
Support Year
22
Fiscal Year
2002
Total Cost
$35,882
Indirect Cost
Name
Johns Hopkins University
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Iben, James R; Draper, David E (2008) Specific interactions of the L10(L12)4 ribosomal protein complex with mRNA, rRNA, and L11. Biochemistry 47:2721-31
Maeder, Corina; Conn, Graeme L; Draper, David E (2006) Optimization of a ribosomal structural domain by natural selection. Biochemistry 45:6635-43
Bausch, Sarae L; Poliakova, Ekaterina; Draper, David E (2005) Interactions of the N-terminal domain of ribosomal protein L11 with thiostrepton and rRNA. J Biol Chem 280:29956-63
Maeder, Corina; Draper, David E (2005) A small protein unique to bacteria organizes rRNA tertiary structure over an extensive region of the 50 S ribosomal subunit. J Mol Biol 354:436-46
Conn, Graeme L; Gittis, Apostolos G; Lattman, Eaton E et al. (2002) A compact RNA tertiary structure contains a buried backbone-K+ complex. J Mol Biol 318:963-73
Blyn, L B; Risen, L M; Griffey, R H et al. (2000) The RNA-binding domain of ribosomal protein L11 recognizes an rRNA tertiary structure stabilized by both thiostrepton and magnesium ion. Nucleic Acids Res 28:1778-84
Shiman, R; Draper, D E (2000) Stabilization of RNA tertiary structure by monovalent cations. J Mol Biol 302:79-91
GuhaThakurta, D; Draper, D E (2000) Contributions of basic residues to ribosomal protein L11 recognition of RNA. J Mol Biol 295:569-80
Conn, G L; Draper, D E; Lattman, E E et al. (1999) Crystal structure of a conserved ribosomal protein-RNA complex. Science 284:1171-4
Draper, D E (1999) Themes in RNA-protein recognition. J Mol Biol 293:255-70

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