Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37GM029595-18
Application #
2175576
Study Section
Special Emphasis Panel (NSS)
Project Start
1987-09-01
Project End
1998-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
18
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Massachusetts Institute of Technology
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
City
Cambridge
State
MA
Country
United States
Zip Code
02139
Olshansky, Lisa; Stubbe, JoAnne; Nocera, Daniel G (2016) Charge-Transfer Dynamics at the ?/? Subunit Interface of a Photochemical Ribonucleotide Reductase. J Am Chem Soc 138:1196-205
Ando, Nozomi; Li, Haoran; Brignole, Edward J et al. (2016) Allosteric Inhibition of Human Ribonucleotide Reductase by dATP Entails the Stabilization of a Hexamer. Biochemistry 55:373-81
Koo, Bon Jun; Huynh, Michael; Halbach, Robert L et al. (2015) Modulation of Phenol Oxidation in Cofacial Dyads. J Am Chem Soc 137:11860-3
Doan, Peter E; Shanmugam, Muralidharan; Stubbe, JoAnne et al. (2015) Composition and Structure of the Inorganic Core of Relaxed Intermediate X(Y122F) of Escherichia coli Ribonucleotide Reductase. J Am Chem Soc 137:15558-66
Ravichandran, Kanchana R; Minnihan, Ellen C; Wei, Yifeng et al. (2015) Reverse Electron Transfer Completes the Catalytic Cycle in a 2,3,5-Trifluorotyrosine-Substituted Ribonucleotide Reductase. J Am Chem Soc 137:14387-95
Nick, Thomas U; Lee, Wankyu; Kossmann, Simone et al. (2015) Hydrogen bond network between amino acid radical intermediates on the proton-coupled electron transfer pathway of E. coli ?2 ribonucleotide reductase. J Am Chem Soc 137:289-98
Olshansky, Lisa; Pizano, Arturo A; Wei, Yifeng et al. (2014) Kinetics of hydrogen atom abstraction from substrate by an active site thiyl radical in ribonucleotide reductase. J Am Chem Soc 136:16210-6
Wei, Yifeng; Mathies, Guinevere; Yokoyama, Kenichi et al. (2014) A chemically competent thiosulfuranyl radical on the Escherichia coli class III ribonucleotide reductase. J Am Chem Soc 136:9001-13
Wei, Yifeng; Funk, Michael A; Rosado, Leonardo A et al. (2014) The class III ribonucleotide reductase from Neisseria bacilliformis can utilize thioredoxin as a reductant. Proc Natl Acad Sci U S A 111:E3756-65
Zhang, Yan; An, Xiuxiang; Stubbe, Joanne et al. (2013) Investigation of in vivo roles of the C-terminal tails of the small subunit (??') of Saccharomyces cerevisiae ribonucleotide reductase: contribution to cofactor formation and intersubunit association within the active holoenzyme. J Biol Chem 288:13951-9

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