Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37GM035906-21
Application #
6835227
Study Section
Special Emphasis Panel (NSS)
Program Officer
Ikeda, Richard A
Project Start
1986-01-01
Project End
2008-12-31
Budget Start
2005-01-01
Budget End
2005-12-31
Support Year
21
Fiscal Year
2005
Total Cost
$400,225
Indirect Cost

  Institution

Name
University of Texas Austin
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
170230239
City
Austin
State
TX
Country
United States
Zip Code
78712

  Publications

Ko, Yeonjin; Lin, Geng-Min; Ruszczycky, Mark W et al. (2018) Mechanistic Implications of the Deamination of TDP-4-amino-4-deoxy-d-fucose Catalyzed by the Radical SAM Enzyme DesII. Biochemistry 57:3130-3133
Besandre, Ronald; Liu, Hung-Wen (2018) Biochemical Basis of Vosevi, a New Treatment for Hepatitis CPublished as part of the Biochemistry series ""Biochemistry to Bedside"". Biochemistry 57:479-480
Ruszczycky, Mark W; Zhong, Aoshu; Liu, Hung-Wen (2018) Following the electrons: peculiarities in the catalytic cycles of radical SAM enzymes. Nat Prod Rep 35:615-621
Lin, Chia-I; McCarty, Reid M; Liu, Hung-Wen (2017) The Enzymology of Organic Transformations: A Survey of Name Reactions in Biological Systems. Angew Chem Int Ed Engl 56:3446-3489
Lin, Geng-Min; Romo, Anthony J; Liem, Priscilla H et al. (2017) Identification and Interrogation of the Herbicidin Biosynthetic Gene Cluster: First Insight into the Biosynthesis of a Rare Undecose Nucleoside Antibiotic. J Am Chem Soc 139:16450-16453
Kim, Hak Joong; Liu, Yung-Nan; McCarty, Reid M et al. (2017) Reaction Catalyzed by GenK, a Cobalamin-Dependent Radical S-Adenosyl-l-methionine Methyltransferase in the Biosynthetic Pathway of Gentamicin, Proceeds with Retention of Configuration. J Am Chem Soc 139:16084-16087
Ko, Yeonjin; Wang, Shao-An; Ogasawara, Yasushi et al. (2017) Identification and Characterization of Enzymes Catalyzing Pyrazolopyrimidine Formation in the Biosynthesis of Formycin A. Org Lett 19:1426-1429
Bridwell-Rabb, Jennifer; Zhong, Aoshu; Sun, He G et al. (2017) A B12-dependent radical SAM enzyme involved in oxetanocin A biosynthesis. Nature 544:322-326
Lin, Geng-Min; Sun, He G; Liu, Hung-Wen (2016) Study of Uridine 5'-Diphosphate (UDP)-Galactopyranose Mutase Using UDP-5-Fluorogalactopyranose as a Probe: Incubation Results and Mechanistic Implications. Org Lett 18:3438-41
Ushimaru, Richiro; Lin, Chia-I; Sasaki, Eita et al. (2016) Characterization of Enzymes Catalyzing Transformations of Cysteine S-Conjugated Intermediates in the Lincosamide Biosynthetic Pathway. Chembiochem 17:1606-11

Showing the most recent 10 out of 103 publications