Abstract

ininstructions on pacp6. Appendix (Five collatedsets. Nopage numberingnecessaryforAppendix.) ?? Check if Number of publications andmanuscripts accepted orsubmitted for publication (not toexceed 10) 10 *^ inSu^ed""""""""'IS Other items (list): PHS 398 (Rev. 4/98) (Form Page 3) Page 3 CC

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37GM038109-23
Application #
7603052
Study Section
Special Emphasis Panel (NSS)
Project Start
1987-04-01
Project End
2010-03-31
Budget Start
2009-04-01
Budget End
2010-03-31
Support Year
23
Fiscal Year
2009
Total Cost
$515,639
Indirect Cost

  Institution

Name
Northwestern University at Chicago
Department
Biochemistry
Type
Schools of Arts and Sciences
DUNS #
160079455
City
Evanston
State
IL
Country
United States
Zip Code
60201

  Publications

Ciryam, Prajwal; Lambert-Smith, Isabella A; Bean, Daniel M et al. (2017) Spinal motor neuron protein supersaturation patterns are associated with inclusion body formation in ALS. Proc Natl Acad Sci U S A 114:E3935-E3943
Kirstein, Janine; Arnsburg, Kristin; Scior, Annika et al. (2017) In vivo properties of the disaggregase function of J-proteins and Hsc70 in Caenorhabditis elegans stress and aging. Aging Cell 16:1414-1424
Labbadia, Johnathan; Morimoto, Richard I (2015) Repression of the Heat Shock Response Is a Programmed Event at the Onset of Reproduction. Mol Cell 59:639-50
Teixeira-Castro, Andreia; Jalles, Ana; Esteves, Sofia et al. (2015) Serotonergic signalling suppresses ataxin 3 aggregation and neurotoxicity in animal models of Machado-Joseph disease. Brain 138:3221-37
Labbadia, Johnathan; Morimoto, Richard I (2015) The biology of proteostasis in aging and disease. Annu Rev Biochem 84:435-64
Brandvold, Kristoffer R; Morimoto, Richard I (2015) The Chemical Biology of Molecular Chaperones--Implications for Modulation of Proteostasis. J Mol Biol 427:2931-47
Brehme, Marc; Voisine, Cindy; Rolland, Thomas et al. (2014) A chaperome subnetwork safeguards proteostasis in aging and neurodegenerative disease. Cell Rep 9:1135-50
van Oosten-Hawle, Patricija; Morimoto, Richard I (2014) Organismal proteostasis: role of cell-nonautonomous regulation and transcellular chaperone signaling. Genes Dev 28:1533-43
Ryno, Lisa M; Genereux, Joseph C; Naito, Tadasuke et al. (2014) Characterizing the altered cellular proteome induced by the stress-independent activation of heat shock factor 1. ACS Chem Biol 9:1273-83
Roth, Daniela Martino; Hutt, Darren M; Tong, Jiansong et al. (2014) Modulation of the maladaptive stress response to manage diseases of protein folding. PLoS Biol 12:e1001998

Showing the most recent 10 out of 67 publications