Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
4R37GM040198-22
Application #
6966319
Study Section
Special Emphasis Panel (NSS)
Program Officer
Deatherage, James F
Project Start
1988-01-20
Project End
2010-12-31
Budget Start
2006-01-20
Budget End
2006-12-31
Support Year
22
Fiscal Year
2006
Total Cost
$427,565
Indirect Cost
Name
Wadsworth Center
Department
Type
DUNS #
153695478
City
Menands
State
NY
Country
United States
Zip Code
12204
Lee, Kyunghee; Kenny, Alison E; Rieder, Conly L (2011) Caspase activity is not required for the mitotic checkpoint or mitotic slippage in human cells. Mol Biol Cell 22:2470-9
Yang, Zhenye; Kenny, Alison E; Brito, Daniela A et al. (2009) Cells satisfy the mitotic checkpoint in Taxol, and do so faster in concentrations that stabilize syntelic attachments. J Cell Biol 186:675-84
Rieder, Conly L; Medema, René H (2009) No way out for tumor cells. Cancer Cell 16:274-5
Khodjakov, Alexey; Rieder, Conly L (2009) The nature of cell-cycle checkpoints: facts and fallacies. J Biol 8:88
Brito, Daniela A; Rieder, Conly L (2009) The ability to survive mitosis in the presence of microtubule poisons differs significantly between human nontransformed (RPE-1) and cancer (U2OS, HeLa) cells. Cell Motil Cytoskeleton 66:437-47
DiMaio, Michael A; Mikhailov, Alexei; Rieder, Conly L et al. (2009) The small organic compound HMN-176 delays satisfaction of the spindle assembly checkpoint by inhibiting centrosome-dependent microtubule nucleation. Mol Cancer Ther 8:592-601
Khodjakov, Alexey; Rieder, Conly L (2009) Mitosis: too much of a good thing (can be bad). Curr Biol 19:R1032-4
Brito, Daniela A; Yang, Zhenye; Rieder, Conly L (2008) Microtubules do not promote mitotic slippage when the spindle assembly checkpoint cannot be satisfied. J Cell Biol 182:623-9
Yang, Zhenye; Loncarek, Jadranka; Khodjakov, Alexey et al. (2008) Extra centrosomes and/or chromosomes prolong mitosis in human cells. Nat Cell Biol 10:748-51
Mikhailov, Alexei; Patel, Daksha; McCance, Dennis J et al. (2007) The G2 p38-mediated stress-activated checkpoint pathway becomes attenuated in transformed cells. Curr Biol 17:2162-8

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