The aims of this work are to develop new methods for organic synthesis. In particular, methods to effect the reduction of prochiral functional groups and to effect carbon-carbon bond formation are proposed. The development of new synthetic methods is of central importance to the development of organic synthesis, in particular, and organic chemistry in general. The availability of general and predictable means by which to assemble large numbers of small molecules in both a specific, as well as a combinatorial fashion is key to the uncovering of new lead structures in drug discovery. Moreover, the ability to quickly generate a diverse set of analogs of the initial lead compounds is essential for the rapid arrival at compounds with improved pharmacological profiles. In recent years, a growing emphasis on the preparation of single enantiomer compounds as pharmaceutical agents has prompted intensive activity in the area of asymmetric synthesis. Asymmetric catalysis offers a particularly efficient means to enhance access to pharmaceutical agents of a single """"""""handedness."""""""" Many of the applications described in this proposal, including the preparation of enantiomerically pure amines, biaryls and cycloalkones could have an immediate impact on the efficient access to a variety of important molecules, be they lead compounds in drug discovery, or analogs of the initial leads that possess a better pharmacological profile.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37GM046059-15
Application #
7118228
Study Section
Special Emphasis Panel (NSS)
Program Officer
Schwab, John M
Project Start
1992-08-01
Project End
2010-07-31
Budget Start
2006-08-01
Budget End
2007-07-31
Support Year
15
Fiscal Year
2006
Total Cost
$902,164
Indirect Cost
Name
Massachusetts Institute of Technology
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
001425594
City
Cambridge
State
MA
Country
United States
Zip Code
02139
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