The objective of this research is to increase our understanding of the neurobiological processes involved in modulating the storage of newly-acquired information.
The specific aim of this research project is to investigate the interaction of amygdala noradrenergic and opiate receptor systems in modulating memory storage. Rats implanted bilaterally with amygdala cannulae will be trained on a Y-maze discrimination task and given posttraining systemic and/or intra-amygdala injections. Retention will be tested one week later by training the animals on a reversed discrimination. A first set of experiments will examine the effects, on memory, of current intra-amygdala injections of agonists and antagonists affecting the two systems. A second set of experiments will examine the effects of posttraining administration of adrenergic and opiate agonists and antagonists on memory in animals given intra-amygdala injections of 6-OHDA one week prior to training. A third set of experiments will determine whether intra-amygdala injections of antagonists of one of these two receptor systems alter the effects, on memory storage, of systemic injections of compounds affecting the other receptor system. A fourth set of experiments will examine the effects, on memory, of posttraining administration of noradrenergic and opioid agonists and antagonists into other brain regions including the ventral hippocampus and the caudate- putamen. A fifth set of experiments will investigate the effects, on retention, of posttraining injections of noradrenergic and opioid compounds into specific nuclei within the amygdaloid complex. The findings of this research will increase our understanding of brain systems involved in the modulation of memory storage processes and, thus should have implications for understanding and, ultimately, treating disorders of memory.
| Ferry, Barbara; Parrot, Sandrine; Marien, Marc et al. (2015) Noradrenergic influences in the basolateral amygdala on inhibitory avoidance memory are mediated by an action on ?2-adrenoceptors. Psychoneuroendocrinology 51:68-79 |
| McGaugh, James L (2015) Consolidating memories. Annu Rev Psychol 66:1-24 |
| Chavez, Candice M; McGaugh, James L; Weinberger, Norman M (2013) Activation of the basolateral amygdala induces long-term enhancement of specific memory representations in the cerebral cortex. Neurobiol Learn Mem 101:8-18 |
| Patihis, Lawrence; Frenda, Steven J; LePort, Aurora K R et al. (2013) False memories in highly superior autobiographical memory individuals. Proc Natl Acad Sci U S A 110:20947-52 |
| McGaugh, James L (2013) Making lasting memories: remembering the significant. Proc Natl Acad Sci U S A 110 Suppl 2:10402-7 |
| McIntyre, Christa K; McGaugh, James L; Williams, Cedric L (2012) Interacting brain systems modulate memory consolidation. Neurosci Biobehav Rev 36:1750-62 |
| Roozendaal, Benno; McGaugh, James L (2011) Memory modulation. Behav Neurosci 125:797-824 |
| Barsegyan, Areg; Mackenzie, Scott M; Kurose, Brian D et al. (2010) Glucocorticoids in the prefrontal cortex enhance memory consolidation and impair working memory by a common neural mechanism. Proc Natl Acad Sci U S A 107:16655-60 |
| McGaugh, James L; Roozendaal, Benno (2009) Drug enhancement of memory consolidation: historical perspective and neurobiological implications. Psychopharmacology (Berl) 202:3-14 |
| Roozendaal, Benno; McReynolds, Jayme R; Van der Zee, Eddy A et al. (2009) Glucocorticoid effects on memory consolidation depend on functional interactions between the medial prefrontal cortex and basolateral amygdala. J Neurosci 29:14299-308 |
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