Project Start
Project End
Budget Start
Budget End
Support Year
12
Fiscal Year
1990
Total Cost
Indirect Cost
Name
Tufts University
Department
Type
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02111
Warrington, Jill S; Greenblatt, David J; von Moltke, Lisa L (2004) Age-related differences in CYP3A expression and activity in the rat liver, intestine, and kidney. J Pharmacol Exp Ther 309:720-9
Greenblatt, David J; Von Moltke, Lisa L; Giancarlo, Gina M et al. (2003) Human cytochromes mediating gepirone biotransformation at low substrate concentrations. Biopharm Drug Dispos 24:87-94
Bertelsen, Kirk M; Venkatakrishnan, Karthik; Von Moltke, Lisa L et al. (2003) Apparent mechanism-based inhibition of human CYP2D6 in vitro by paroxetine: comparison with fluoxetine and quinidine. Drug Metab Dispos 31:289-93
Tran, Thanh Huu; Von Moltke, Lisa L; Venkatakrishnan, Karthik et al. (2002) Microsomal protein concentration modifies the apparent inhibitory potency of CYP3A inhibitors. Drug Metab Dispos 30:1441-5
Stormer, Elke; von Moltke, Lisa L; Perloff, Michael D et al. (2002) Differential modulation of P-glycoprotein expression and activity by non-nucleoside HIV-1 reverse transcriptase inhibitors in cell culture. Pharm Res 19:1038-45
Perloff, Michael D; von Moltke, Lisa L; Greenblatt, David J (2002) Fexofenadine transport in Caco-2 cells: inhibition with verapamil and ritonavir. J Clin Pharmacol 42:1269-74
Olubodun, Joel O; Ochs, Hermann R; Truten, Volker et al. (2002) Zolpidem pharmacokinetic properties in young females: influence of smoking and oral contraceptive use. J Clin Pharmacol 42:1142-6
Laurijssens, Bart E; Greenblatt, David J (2002) Effect of 7-day exposure to midazolam on electroencephalogram pharmacodynamics in rats: a model to study multiple pharmacokinetic-pharmacodynamic relationships in individual animals. J Pharm Pharmacol 54:77-86
Warrington, Jill S; Von Moltke, Lisa L; Shader, Richard I et al. (2002) In vitro biotransformation of sildenafil (Viagra) in the male rat: the role of CYP2C11. Drug Metab Dispos 30:655-7
Venkatakrishnan, Karthik; Von Moltke, Lisa L; Greenblatt, David J (2002) Evaluation of Supermix as an in vitro model of human liver microsomal drug metabolism. Biopharm Drug Dispos 23:183-90

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