The integrated scientific team of INphoton, LLC will develop standard operating procedures for intravital multiphoton microscopy assays quantifying fluorescent drug delivery, cellular uptake, intracellular distribution, metabolism, and physiologic/therapeutic effects within the kidney of live rats. Refinement of some existing assays will be necessary for commercial utilization. The resulting products will enable INphoton to extend commercial services to pharmaceutical and biotech companies to enhance preclinical evaluation of potential products. INphoton, LLC will commercialize multiphoton microscopy for preclinical drug evaluation in the kidney. This will greatly aid evaluation of a potential therapeutic agent's cellular location, functional effects and adverse affects. Since this is not possible with other imaging modalities, this approach complements and extends existing imaging technologies. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Small Business Technology Transfer (STTR) Grants - Phase I (R41)
Project #
1R41DK076478-01A1
Application #
7218512
Study Section
Special Emphasis Panel (ZRG1-RUS-C (11))
Program Officer
Moxey-Mims, Marva M
Project Start
2007-02-01
Project End
2009-01-31
Budget Start
2007-02-01
Budget End
2009-01-31
Support Year
1
Fiscal Year
2007
Total Cost
$100,000
Indirect Cost
Name
Inphoton, LLC
Department
Type
DUNS #
612993936
City
Indianapolis
State
IN
Country
United States
Zip Code
46260
Sandoval, Ruben M; Wagner, Mark C; Patel, Monica et al. (2012) Multiple factors influence glomerular albumin permeability in rats. J Am Soc Nephrol 23:447-57