The proposed research is designed to demonstrate the efficacy of Phase-Modulated Near Infrared Spectroscopy (NIRS) in the in-vivo detection of cerebral oxygenation levels by quantitatively measuring cerebral oxygenated hemoglobin (Hb02) and de-oxygenated hemoglobin (Hb). This research also will build a foundation for human studies and the eventual commercialization of this technology, particularly in neonatal applications. The specific research plan is to evaluate a Phase Modulated NIRS instrument recently built by InnerVision Diagnostics by completing tests on a series of non-human models.
the specific aims are: 1.) to compare the concentrations of a compound as determined by Phase-Modulated NIRS with its known concentration in a static phantom brain model. 2.) to compare the concentrations of oxy- and deoxy- hemoglobin concentration and hemoglobin-02 saturation in a dynamic phantom brain as determined by Phase-Modulated NIR spectroscopy with co- oximetry. 3.) to compare the concentrations of oxy- and deoxy - hemoglobin concentration and hemoglobin- 02 saturation in a piglet brain as determined by Phase-Modulated NIR spectroscopy with co-oximetry. 4) To provide recommendations on how instrumentation can be advanced to address any limitations discovered in the course of this study.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Small Business Technology Transfer (STTR) Grants - Phase I (R41)
Project #
1R41HD034012-01
Application #
2207566
Study Section
Special Emphasis Panel (ZRG7-SSS-6 (03))
Project Start
1995-08-18
Project End
1996-08-15
Budget Start
1995-08-18
Budget End
1996-08-15
Support Year
1
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Inner Vision Diagnostics, Inc.
Department
Type
DUNS #
City
Somerville
State
MA
Country
United States
Zip Code
02144