) The goal of this SBIR application is to develop [1-123]-labeled sigma-2 receptor imaging agents for Single Photon Emission Computed Tomography (SPECT) studies of breast cancer. This approach is based on the observation that sigma-2 receptors are expressed in high density in a number of human tumors, including breast tumors. Our preliminary data also indicate that [1-123]-labeled sigma-2 receptor imaging radiotracers can not only be used in the anatomical imaging of breast tumors, but may also provide information regarding the proliferative status of breast cancer. An additional incentive for focusing on sigma-2 receptors stems from our development of a number of new sigma-2 selective compounds that will serve as lead compounds for SPECT radiotracer development. There are currently no sigma-2 selective radiotracers for SPECT imaging studies of breast cancer. The strategy chosen for incorporating [1-123] into the promising compounds will use established methods developed for making [1-123]-labeled receptor imaging agents. Although the proposed radiopharmaceuticals will initially benefit the diagnosis and treament of breast cancer, we believe the technology developed in this SBIR application will translate to other human cancers (lung carcinoma, gliomas, etc.) that possess a high density of sigma-2 receptors.

Proposed Commercial Applications

NOT AVAILABLE

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Small Business Innovation Research Grants (SBIR) - Phase I (R43)
Project #
1R43CA088389-01
Application #
6203901
Study Section
Special Emphasis Panel (ZCA1-SRRB-C (M1))
Program Officer
Torres-Anjel, Manuel J
Project Start
2001-05-01
Project End
2002-07-31
Budget Start
2001-05-01
Budget End
2002-07-31
Support Year
1
Fiscal Year
2001
Total Cost
$132,000
Indirect Cost
Name
Anasazi Biomedical Research, Inc.
Department
Type
DUNS #
City
Winston-Salem
State
NC
Country
United States
Zip Code
27101