A keratoscope is a standard device for measuring the shape or me cornea. unfortunately, it cannot take measurements from diffuse corneal surfaces after photorefractive keratectomy (PRK), when such measurements are needed. A tradeoff in keratoscope principles is involved: whether to make the pinhole as small as possible to maintain the operative principles of the device or to emphasize maximum measurement precision. In answer to the National Institutes of Health's request for new methods of measuring the optical properties of the cornea, Physical Optics Corporation (POC) proposes a nonscanning speckle interferometer (NSI) that will measure corneal shape and radius during and immediately following photorefractive keratectomy (PRK). The NSI, based on a well-known principle for optical testing of rough surfaces, incorporates important improvements, including an acousto-optic deflector for creating a beam rake with frequency shift for nonscanning measuring, fiber optic wavelength division-multiplexing technology, and principles of absolute distance interferometry developed by implementing the Chinese remainders theorem. The NSI is flexible, allowing measurement of the corneal shape in diffuse surface zones after PRK; smooth zones are also accessible because of the special position of the exit pupil in the focusing lens. Shape measuring precision is about 0.1 microm, and is defined mostly by surface roughness.

Proposed Commercial Applications

The nonscanning speckle interferometer will permit surgeons to safely monitor the shape of a cornea during surgery. The device will be useful following surgery for mapping the corneal surface. Commercial market demand for such an instrument already exists in clinics and doctors' offices.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Small Business Innovation Research Grants (SBIR) - Phase I (R43)
Project #
1R43EY011960-01A2
Application #
2798534
Study Section
Special Emphasis Panel (ZRG1-VISA (02))
Project Start
1999-07-01
Project End
1999-12-31
Budget Start
1999-07-01
Budget End
1999-12-31
Support Year
1
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Physical Optics Corporation
Department
Type
DUNS #
City
Torrance
State
CA
Country
United States
Zip Code
90501