The long term objective of this project is to provide an instrumentation for diagnosing and quantification of the retinal changes associated with age-related macular degeneration (ARM) and age related maculopathy (AMD). The approach employed here is to integrate a multiply scattered light imaging mechanism into a confocal imaging system to obtain qualitative and quantitative diagnosis of subretinal structures and their changes. The system to be developed will be based on a Topographic Scanning System TopSSTM (Laser Diagnostic Technologies, Inc.). Vertical Cavity Surface Emitting Laser Arrays (VCSELs) will be implemented to provide an illumination source for both confocal imaging mode and multiply scattered light imaging mode. Phase I work of this project will start with hardware modifications of the existing TopSSTM system to implement the multiply scattered light imaging mode; clinical studies will then be carried out to test the feasibility of diagnosing subretinal changes associated with ARM and AMD using the modified TopSSTM system; software for measurement of the 3-dimensional subretinal structure and quantification of their changes will also be developed.

Proposed Commercial Applications

NOT AVAILABLE

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Small Business Innovation Research Grants (SBIR) - Phase I (R43)
Project #
1R43EY012178-01
Application #
2650431
Study Section
Special Emphasis Panel (ZRG1-VISA (02))
Project Start
1998-08-01
Project End
1999-01-31
Budget Start
1998-08-01
Budget End
1999-01-31
Support Year
1
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Laser Diagnostic Technologies, Inc.
Department
Type
DUNS #
City
San Diego
State
CA
Country
United States
Zip Code
92127