This is a Phase I proposal to begin development of a comprehensive computer software package for the management, simulation, and analysis using Gibbs sampling, of pedigree data. To this end, pedigree data management and simulation components of the package will be developed and tested. Currently available Gibbs sampling methods of analysis will be assessed, and extensions will be evaluated as to their feasibility for inclusion within the time frame of Phase II. The proposed package will fill a void in the currently available array of programs for the analysis of pedigree data. The goal for the final package, to be completed in Phase II, includes all of the following: combined segregation and linkage analysis, inclusion of environmental covariates, adjustment for censored age at disease onset, gene-environment interactions, ascertainment correction, estimation of allele frequencies and allowance for missing data. In addition to comprehensive analysis capabilities, potential users will enjoy a convenient, easy-to-use interface between the management, analysis, and simulation components of the program.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Small Business Innovation Research Grants (SBIR) - Phase I (R43)
Project #
1R43GM048326-01
Application #
3498862
Study Section
Special Emphasis Panel (SSS (BA))
Project Start
1992-09-01
Project End
1993-03-31
Budget Start
1992-09-01
Budget End
1993-03-31
Support Year
1
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Epicenter Software
Department
Type
DUNS #
City
Pasadena
State
CA
Country
United States
Zip Code
91106