An effective oral male antifertility agent, which is both non-toxic and reversible, is not currently available. Gossypol, the most promising non-steroidal male antifertility lead, has an unacceptably narrow therapeutic ratio. We propose that the therapeutic ratio may be improved by alteration of the pharmaco-kinetics and bioavailability through water-solubilization. Accordingly, several carefully chosen water-soluble derivatives of gossypol will be prepared. These compounds will then be tested for both in vitro spermicidal activity and in vivo antifertility activity. The in vivo tests will be evaluated both in terms of efficacy and toxicity. The identification of a compound with the same efficacy as gossypol but without the toxic effects would provide the basis for further study leading to the eventual development of a safe and effective male antifertility agent.

Project Start
1985-09-01
Project End
1986-11-15
Budget Start
1985-09-01
Budget End
1986-11-15
Support Year
1
Fiscal Year
1985
Total Cost
Indirect Cost
Name
H. G. Pars Laboratories, Inc.
Department
Type
DUNS #
City
Lexington
State
MA
Country
United States
Zip Code
Wallace, J M; Luther, J S; Milne, J S et al. (2006) Nutritional modulation of adolescent pregnancy outcome -- a review. Placenta 27 Suppl A:S61-8