The objective of this project is to develop a grid-free CFD software for the simulation and analysis of the complex dynamics of the Fluid-Structure Interaction (FSI) associated with Mechanical Prosthetic Heart Valve (MPHV) """"""""systems"""""""" as they respond to physiologically realistic 3-D pulsatile flow, which includes laminar and turbulent flow regimes as well as transition between the two regimes. The final product will be the first commercially available grid-free """"""""virtual MPHV test chamber"""""""", which can be used by scientists and heart valve designers, for example, to investigate new hypotheses on the hemodynamic aspect of cardiac physiology; to perform parametric studies in order to design new or to improve existing prosthetic valves; or to establish criteria for MPHV implantation (e.g. orientation) under which valve performance will be acceptable.
The research aims specifically at (1) coupling an existing MPI-parallel, fast Lagrangian vortex element method with a structural dynamics code, and (2) validating the resultant software using physiologically realistic test cases.
| Gaubatz, J W; Hoogeveen, R C; Hoffman, A S et al. (2001) Isolation, quantitation, and characterization of a stable complex formed by Lp[a] binding to triglyceride-rich lipoproteins. J Lipid Res 42:2058-68 |
