Abstract

Human apyrase represents a highly promising therapy for treatment of acute myocardial infarction. This enzyme strongly inhibits platelet activation and aggregation with modest bleeding risk. Using a protein informatics approach, we have successfully engineered human apyrases which exhibit both antiplatelet and anti-inflammatory activities. With the Phase I grant support, we will determine whether optimized human apyrases, in combination with tPA, induce rapid and sustained coronary artery recanalization without increasing bleeding risk.

Public Health Relevance

We will utilize a coronary thrombotic model in dogs to validate whether human apyrase more effectively improve coronary patency than clopidogrel without increasing bleeding risk.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Small Business Innovation Research Grants (SBIR) - Phase I (R43)
Project #
1R43HL095169-01A1
Application #
7744087
Study Section
Special Emphasis Panel (ZRG1-HEME-D (10))
Program Officer
Sarkar, Rita
Project Start
2009-08-07
Project End
2011-07-31
Budget Start
2009-08-07
Budget End
2011-07-31
Support Year
1
Fiscal Year
2009
Total Cost
$226,120
Indirect Cost

  Institution

Name
Apt Therapeutics, Inc.
Department
Type
DUNS #
192266141
City
Saint Louis
State
MO
Country
United States
Zip Code
63108

  Publications

Vella, Chantal A; Cushman, Mary; Van Hollebeke, Rachel B et al. (2018) Associations of Abdominal Muscle Area and Radiodensity with Adiponectin and Leptin: The Multiethnic Study of Atherosclerosis. Obesity (Silver Spring) 26:1234-1241
Kaiser, Paulina; Peralta, Carmen A; Kronmal, Richard et al. (2018) Racial/ethnic heterogeneity in associations of blood pressure and incident cardiovascular disease by functional status in a prospective cohort: the Multi-Ethnic Study of Atherosclerosis. BMJ Open 8:e017746
Vella, Chantal A; Allison, Matthew A (2018) Associations of abdominal intermuscular adipose tissue and inflammation: The Multi-Ethnic Study of Atherosclerosis. Obes Res Clin Pract 12:534-540
Cainzos-Achirica, Miguel; Miedema, Michael D; McEvoy, John W et al. (2018) The prognostic value of high sensitivity C-reactive protein in a multi-ethnic population after >10?years of follow-up: The Multi-Ethnic Study of Atherosclerosis (MESA). Int J Cardiol 264:158-164
Basu, Sanjay; Sussman, Jeremy B; Berkowitz, Seth A et al. (2018) Validation of Risk Equations for Complications of Type 2 Diabetes (RECODe) Using Individual Participant Data From Diverse Longitudinal Cohorts in the U.S. Diabetes Care 41:586-595
Osibogun, Olatokunbo; Ogunmoroti, Oluseye; Spatz, Erica S et al. (2018) Is self-rated health associated with ideal cardiovascular health? The Multi-Ethnic Study of Atherosclerosis. Clin Cardiol 41:1154-1163
Thomas, Isac C; McClelland, Robyn L; Allison, Matthew A et al. (2018) Progression of calcium density in the ascending thoracic aorta is inversely associated with incident cardiovascular disease events. Eur Heart J Cardiovasc Imaging 19:1343-1350
Raffield, Laura M; Ellis, Jaclyn; Olson, Nels C et al. (2018) Genome-wide association study of homocysteine in African Americans from the Jackson Heart Study, the Multi-Ethnic Study of Atherosclerosis, and the Coronary Artery Risk in Young Adults study. J Hum Genet 63:327-337
Johnson, Dayna A; Hirsch, Jana A; Moore, Kari A et al. (2018) Associations Between the Built Environment and Objective Measures of Sleep: The Multi-Ethnic Study of Atherosclerosis. Am J Epidemiol 187:941-950
Ricalde, Aldrich; Allison, Matthew; Rifkin, Dena et al. (2018) Anthropometric measures of obesity and renal artery calcification: Results from the Multi-Ethnic Study of Atherosclerosis. Atherosclerosis 271:142-147

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