Abstract

Human apyrase represents a highly promising therapy for treatment of acute myocardial infarction. This enzyme strongly inhibits platelet activation and aggregation with modest bleeding risk. Using a protein informatics approach, we have successfully engineered human apyrases which exhibit both antiplatelet and anti-inflammatory activities. With the Phase I grant support, we will determine whether optimized human apyrases, in combination with tPA, induce rapid and sustained coronary artery recanalization without increasing bleeding risk.

Public Health Relevance

We will utilize a coronary thrombotic model in dogs to validate whether human apyrase more effectively improve coronary patency than clopidogrel without increasing bleeding risk.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Small Business Innovation Research Grants (SBIR) - Phase I (R43)
Project #
1R43HL095169-01A1
Application #
7744087
Study Section
Special Emphasis Panel (ZRG1-HEME-D (10))
Program Officer
Sarkar, Rita
Project Start
2009-08-07
Project End
2011-07-31
Budget Start
2009-08-07
Budget End
2011-07-31
Support Year
1
Fiscal Year
2009
Total Cost
$226,120
Indirect Cost

  Institution

Name
Apt Therapeutics, Inc.
Department
Type
DUNS #
192266141
City
Saint Louis
State
MO
Country
United States
Zip Code
63108

  Publications

Ostovaneh, Mohammad R; Ambale-Venkatesh, Bharath; Fuji, Tomoki et al. (2018) Association of Liver Fibrosis With Cardiovascular Diseases in the General Population: The Multi-Ethnic Study of Atherosclerosis (MESA). Circ Cardiovasc Imaging 11:e007241
Zhang, Yiyi; Guallar, Eliseo; Malhotra, Saurabh et al. (2018) Carotid Artery Wall Thickness and Incident Cardiovascular Events: A Comparison between US and MRI in the Multi-Ethnic Study of Atherosclerosis (MESA). Radiology 289:649-657
Zhao, Di; Guallar, Eliseo; Ouyang, Pamela et al. (2018) Endogenous Sex Hormones and Incident Cardiovascular Disease in Post-Menopausal Women. J Am Coll Cardiol 71:2555-2566
Hong, Jaeyoung; Hatchell, Kathryn E; Bradfield, Jonathan P et al. (2018) Transethnic Evaluation Identifies Low-Frequency Loci Associated With 25-Hydroxyvitamin D Concentrations. J Clin Endocrinol Metab 103:1380-1392
Jones, Miranda R; Tellez-Plaza, Maria; Vaidya, Dhananjay et al. (2018) Ethnic, geographic and dietary differences in arsenic exposure in the multi-ethnic study of atherosclerosis (MESA). J Expo Sci Environ Epidemiol :
Emdin, Connor A; Khera, Amit V; Chaffin, Mark et al. (2018) Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease. Nat Commun 9:1613
Flueckiger, Peter; Longstreth, Will; Herrington, David et al. (2018) Revised Framingham Stroke Risk Score, Nontraditional Risk Markers, and Incident Stroke in a Multiethnic Cohort. Stroke 49:363-369
Bhatraju, Pavan K; Zelnick, Leila R; Shlipak, Michael et al. (2018) Association of Soluble TNFR-1 Concentrations with Long-Term Decline in Kidney Function: The Multi-Ethnic Study of Atherosclerosis. J Am Soc Nephrol 29:2713-2721
Ong, Kwok Leung; Morris, Margaret J; McClelland, Robyn L et al. (2018) Relationship of Lipids and Lipid-Lowering Medications With Cognitive Function: The Multi-Ethnic Study of Atherosclerosis. Am J Epidemiol 187:767-776
Xu, Jiayi; Bartz, Traci M; Chittoor, Geetha et al. (2018) Meta-analysis across Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium provides evidence for an association of serum vitamin D with pulmonary function. Br J Nutr 120:1159-1170

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