Despite new rapid image acquisition techniques high-quality MRI data requires data collection times of several seconds or minutes. Any kind of uncompensated object movement on this time scale will lead to blurring, ghosting or other artifacts in the resulting images. All currently available motion correction schemes employ triggering, gating or some sort of navigator echo, which frequently give rise to large amounts of rejected data, compromised image quality or a significant amount of residual blurring. We are proposing a hybrid approach that employs ultrasound images to monitor the position of the target organ. The spatial information is then passed along to the MRI scanner which adjusts the slice orientation accordingly. This method effectively allows to perform the MR image acquisition in the reference frame of the moving organ and not that of the stationary MRI scanner, Ultrasound-guided MRI should permit dramatic improvements in imaging the heart or abdominal organs that are affected by physiological motion.

Proposed Commercial Applications

The proposed ultrasound-guided MRI technology will be made available for MRI scanners of all major MR hardware manufacturers. Its targeted application is high-resolution cardiac CRI or MRI or abdominal organs affected by physiological motion.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Small Business Innovation Research Grants (SBIR) - Phase I (R43)
Project #
1R43RR017474-01
Application #
6549849
Study Section
Special Emphasis Panel (ZRG1-SSS-7 (11))
Program Officer
Levy, Abraham
Project Start
2002-09-01
Project End
2003-08-31
Budget Start
2002-09-01
Budget End
2003-08-31
Support Year
1
Fiscal Year
2002
Total Cost
$97,125
Indirect Cost
Name
Advanced MRI Technology, LLC
Department
Type
DUNS #
City
Sebastopol
State
CA
Country
United States
Zip Code
95472
Feinberg, David A; Giese, Daniel; Bongers, D Andre et al. (2010) Hybrid ultrasound MRI for improved cardiac imaging and real-time respiration control. Magn Reson Med 63:290-6
Gunther, Matthias; Feinberg, David A (2004) Ultrasound-guided MRI: preliminary results using a motion phantom. Magn Reson Med 52:27-32