Abstract

This is a Shannon Award providing partial support for research projects that fall short of the assigned institute's funding range but are in the margin of excellence. The Shannon award is intended to provide support to test the feasibility of the approach; develop further tests and refine research techniques; perform secondary analysis of available data sets; or conduct discrete projects that can demonstrate the PI's research capabilities or lend additional weight to an already meritorious application. Further scientific data for the CRISP System are unavailable at this time.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
James A. Shannon Director's Award (R55)
Project #
2R55AI010085-28
Application #
3509480
Study Section
Bacteriology and Mycology Subcommittee 2 (BM)
Project Start
1991-09-30
Project End
1992-05-31
Budget Start
1991-09-30
Budget End
1992-05-31
Support Year
28
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
University of Tennessee Health Science Center
Department
Type
Schools of Medicine
DUNS #
941884009
City
Memphis
State
TN
Country
United States
Zip Code
38163

  Publications

Dale, James B; Niedermeyer, Shannon E; Agbaosi, Tina et al. (2015) Protective immunogenicity of group A streptococcal M-related proteins. Clin Vaccine Immunol 22:344-50
Niedermeyer, Shannon E; Penfound, Thomas A; Hohn, Claudia et al. (2014) Group A streptococcus expresses a trio of surface proteins containing protective epitopes. Clin Vaccine Immunol 21:1421-5
Klonoski, Joshua M; Hurtig, Heather R; Juber, Brian A et al. (2014) Vaccination against the M protein of Streptococcus pyogenes prevents death after influenza virus: S. pyogenes super-infection. Vaccine 32:5241-9
Steer, Andrew C; Dale, James B; Carapetis, Jonathan R (2013) Progress toward a global group a streptococcal vaccine. Pediatr Infect Dis J 32:180-2
Dale, James B; Penfound, Thomas A; Chiang, Edna Y et al. (2011) New 30-valent M protein-based vaccine evokes cross-opsonic antibodies against non-vaccine serotypes of group A streptococci. Vaccine 29:8175-8
Penfound, Thomas A; Chiang, Edna Y; Ahmed, Elwaleed A et al. (2010) Protective efficacy of group A streptococcal vaccines containing type-specific and conserved M protein epitopes. Vaccine 28:5017-22
Penfound, Thomas A; Ofek, Itzhak; Courtney, Harry S et al. (2010) The NH(2)-terminal region of Streptococcus pyogenes M5 protein confers protection against degradation by proteases and enhances mucosal colonization of mice. J Infect Dis 201:1580-8
Ahmed, E A; Penfound, T A; Brewer, S C et al. (2010) Streptococcal protective antigens (Spa): a new family of type-specific proteins of group A streptococci. Eur J Clin Microbiol Infect Dis 29:51-7
Cox, Kathleen H; Ruiz-Bustos, Eduardo; Courtney, Harry S et al. (2009) Inactivation of DltA modulates virulence factor expression in Streptococcus pyogenes. PLoS One 4:e5366
Courtney, Harry S; Ofek, Itzhak; Penfound, Thomas et al. (2009) Relationship between expression of the family of M proteins and lipoteichoic acid to hydrophobicity and biofilm formation in Streptococcus pyogenes. PLoS One 4:e4166