Abstract

This is a Shannon Award providing partial support for research projects that fall short of the assigned institute's funding range but are in the margin of excellence. The Shannon award is intended to provide support to test the feasibility of the approach; develop further tests and refine research techniques; perform secondary analysis of available data sets; or conduct discrete projects that can demonstrate the PI's research capabilities or lend additional weight to an already meritorious application. Further scientific data for the CRISP System are unavailable at this time.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
James A. Shannon Director's Award (R55)
Project #
1R55DK044525-01A1
Application #
3509710
Study Section
General Medicine A Subcommittee 2 (GMA)
Project Start
1992-09-30
Project End
1993-04-30
Budget Start
1992-09-30
Budget End
1993-04-30
Support Year
1
Fiscal Year
1992
Total Cost
Indirect Cost

  Institution

Name
University of Illinois at Chicago
Department
Type
Schools of Medicine
DUNS #
121911077
City
Chicago
State
IL
Country
United States
Zip Code
60612

  Publications

Patel, Priyank; Asbach, Benedikt; Shteyn, Elina et al. (2015) Brk/Protein tyrosine kinase 6 phosphorylates p27KIP1, regulating the activity of cyclin D-cyclin-dependent kinase 4. Mol Cell Biol 35:1506-22
Chastkofsky, Michael I; Bie, Wenjun; Ball-Kell, Susan M et al. (2015) Protein Tyrosine Kinase 6 Regulates UVB-Induced Signaling and Tumorigenesis in Mouse Skin. J Invest Dermatol 135:2492-2501
Wang, Zebin; Zheng, Yu; Park, Hyun Jung et al. (2013) Targeting FoxM1 effectively retards p53-null lymphoma and sarcoma. Mol Cancer Ther 12:759-67
Zheng, Yu; Tyner, Angela L (2013) Context-specific protein tyrosine kinase 6 (PTK6) signalling in prostate cancer. Eur J Clin Invest 43:397-404
Zheng, Yu; Wang, Zebin; Bie, Wenjun et al. (2013) PTK6 activation at the membrane regulates epithelial-mesenchymal transition in prostate cancer. Cancer Res 73:5426-37
Zheng, Yu; Asara, John M; Tyner, Angela L (2012) Protein-tyrosine kinase 6 promotes peripheral adhesion complex formation and cell migration by phosphorylating p130 CRK-associated substrate. J Biol Chem 287:148-58
Gierut, Jessica J; Mathur, Priya S; Bie, Wenjun et al. (2012) Targeting protein tyrosine kinase 6 enhances apoptosis of colon cancer cells following DNA damage. Mol Cancer Ther 11:2311-20
Park, Hyun Jung; Gusarova, Galina; Wang, Zebin et al. (2011) Deregulation of FoxM1b leads to tumour metastasis. EMBO Mol Med 3:21-34
Wang, Zebin; Park, Hyun Jung; Carr, Janai R et al. (2011) FoxM1 in tumorigenicity of the neuroblastoma cells and renewal of the neural progenitors. Cancer Res 71:4292-302
Brauer, Patrick M; Zheng, Yu; Evans, Mark D et al. (2011) The alternative splice variant of protein tyrosine kinase 6 negatively regulates growth and enhances PTK6-mediated inhibition of ?-catenin. PLoS One 6:e14789

Showing the most recent 10 out of 21 publications