Abstract

This is a Shannon Award providing partial support for research projects that fall short of the assigned institute's funding range but are in the margin of excellence. The Shannon award is intended to provide support to test the feasibility of the approach; develop further tests and refine research techniques; perform secondary analysis of available data sets; or conduct discrete projects that can demonstrate the PI's research capabilities or lend additional weight to an already meritorious application. Further scientific data for the CRISP System are unavailable at this time.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
James A. Shannon Director's Award (R55)
Project #
1R55GM047909-01
Application #
3509831
Study Section
Microbial Physiology and Genetics Subcommittee 2 (MBC)
Project Start
1992-09-30
Project End
1994-08-31
Budget Start
1992-09-30
Budget End
1994-08-31
Support Year
1
Fiscal Year
1992
Total Cost
Indirect Cost

  Institution

Name
Washington University
Department
Type
Schools of Arts and Sciences
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130

  Publications

Babbitt, Shalon E; Sutherland, Molly C; San Francisco, Brian et al. (2015) Mitochondrial cytochrome c biogenesis: no longer an enigma. Trends Biochem Sci 40:446-55
Babbitt, Shalon E; San Francisco, Brian; Bretsnyder, Eric C et al. (2014) Conserved residues of the human mitochondrial holocytochrome c synthase mediate interactions with heme. Biochemistry 53:5261-71
San Francisco, Brian; Bretsnyder, Eric C; Rodgers, Kenton R et al. (2011) Heme ligand identification and redox properties of the cytochrome c synthetase, CcmF. Biochemistry 50:10974-85
Kern, Melanie; Eisel, Florian; Scheithauer, Juliane et al. (2010) Substrate specificity of three cytochrome c haem lyase isoenzymes from Wolinella succinogenes: unconventional haem c binding motifs are not sufficient for haem c attachment by NrfI and CcsA1. Mol Microbiol 75:122-37
Richard-Fogal, Cynthia; Kranz, Robert G (2010) The CcmC:heme:CcmE complex in heme trafficking and cytochrome c biosynthesis. J Mol Biol 401:350-62
Kern, Melanie; Scheithauer, Juliane; Kranz, Robert G et al. (2010) Essential histidine pairs indicate conserved haem binding in epsilonproteobacterial cytochrome c haem lyases. Microbiology 156:3773-81
Richard-Fogal, Cynthia L; Frawley, Elaine R; Bonner, Eric R et al. (2009) A conserved haem redox and trafficking pathway for cofactor attachment. EMBO J 28:2349-59
Kranz, Robert G; Richard-Fogal, Cynthia; Taylor, John-Stephen et al. (2009) Cytochrome c biogenesis: mechanisms for covalent modifications and trafficking of heme and for heme-iron redox control. Microbiol Mol Biol Rev 73:510-28, Table of Contents