Mechanisms of Cardiotoxicity of Antipsychotic Drugs

Flockhart, David Alastair

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of General Medical Sciences (NIGMS)
• Type: James A. Shannon Director's Award (R55)
• Project #: 1R55GM056898-01
• Application #: 2720430
• Study Section: Special Emphasis Panel (ZRG4-ALTX-4 (01))
• Project Start: 1998-02-01
• Project End: 1998-07-31
• Budget Start: 1998-02-01
• Budget End: 1998-07-31
• Support Year: 1
• Fiscal Year: 1998

Institution

• Name: Georgetown University
• Department: Internal Medicine/Medicine
• Type: Schools of Medicine
• DUNS #: 049515844
• City: Washington
• State: DC
• Country: United States
• Zip Code: 20057

Publications

Shin, J G; Kane, K; Flockhart, D A (2001) Potent inhibition of CYP2D6 by haloperidol metabolites: stereoselective inhibition by reduced haloperidol. Br J Clin Pharmacol 51:45-52

Ko, J W; Desta, Z; Soukhova, N V et al. (2000) In vitro inhibition of the cytochrome P450 (CYP450) system by the antiplatelet drug ticlopidine: potent effect on CYP2C19 and CYP2D6. Br J Clin Pharmacol 49:343-51

Flockhart, D A; Drici, M D; Kerbusch, T et al. (2000) Studies on the mechanism of a fatal clarithromycin-pimozide interaction in a patient with Tourette syndrome. J Clin Psychopharmacol 20:317-24

Shin, J G; Soukhova, N; Flockhart, D A (1999) Effect of antipsychotic drugs on human liver cytochrome P-450 (CYP) isoforms in vitro: preferential inhibition of CYP2D6. Drug Metab Dispos 27:1078-84

Desta, Z; Kerbusch, T; Flockhart, D A (1999) Effect of clarithromycin on the pharmacokinetics and pharmacodynamics of pimozide in healthy poor and extensive metabolizers of cytochrome P450 2D6 (CYP2D6). Clin Pharmacol Ther 65:10-20