Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
High Priority, Short Term Project Award (R56)
Project #
2R56AI063002-05A2
Application #
8086072
Study Section
Special Emphasis Panel (ZRG1-BST-K (90))
Program Officer
Leitner, Wolfgang W
Project Start
2005-01-01
Project End
2012-06-30
Budget Start
2010-07-01
Budget End
2012-06-30
Support Year
5
Fiscal Year
2010
Total Cost
$357,924
Indirect Cost

  Institution

Name
University of Kansas Lawrence
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
076248616
City
Lawrence
State
KS
Country
United States
Zip Code
66045

  Publications

White, Derek R; Khedri, Zahra; Kiptoo, Paul et al. (2017) Synthesis of a Bifunctional Peptide Inhibitor-IgG1 Fc Fusion That Suppresses Experimental Autoimmune Encephalomyelitis. Bioconjug Chem 28:1867-1877
Badawi, Ahmed H; Kiptoo, Paul; Siahaan, Teruna J (2015) Immune Tolerance Induction against Experimental Autoimmune Encephalomyelitis (EAE) Using A New PLP-B7AP Conjugate that Simultaneously Targets B7/CD28 Costimulatory Signal and TCR/MHC-II Signal. J Mult Scler (Foster City) 2:
Sestak, Joshua; Mullins, Meagan; Northrup, Laura et al. (2013) Single-step grafting of aminooxy-peptides to hyaluronan: a simple approach to multifunctional therapeutics for experimental autoimmune encephalomyelitis. J Control Release 168:334-40
Buyuktimkin, Barlas; Manikwar, Prakash; Kiptoo, Paul K et al. (2013) Vaccinelike and prophylactic treatments of EAE with novel I-domain antigen conjugates (IDAC): targeting multiple antigenic peptides to APC. Mol Pharm 10:297-306
Kiptoo, P; Büyüktimkin, B; Badawi, A H et al. (2013) Controlling immune response and demyelination using highly potent bifunctional peptide inhibitors in the suppression of experimental autoimmune encephalomyelitis. Clin Exp Immunol 172:23-36
Badawi, Ahmed H; Siahaan, Teruna J (2013) Suppression of MOG- and PLP-induced experimental autoimmune encephalomyelitis using a novel multivalent bifunctional peptide inhibitor. J Neuroimmunol 263:20-7
Manikwar, Prakash; Kiptoo, Paul; Badawi, Ahmed H et al. (2012) Antigen-specific blocking of CD4-specific immunological synapse formation using BPI and current therapies for autoimmune diseases. Med Res Rev 32:727-64
Büyüktimkin, Barlas; Wang, Qun; Kiptoo, Paul et al. (2012) Vaccine-like controlled-release delivery of an immunomodulating peptide to treat experimental autoimmune encephalomyelitis. Mol Pharm 9:979-85
Badawi, Ahmed H; Siahaan, Teruna J (2012) Immune modulating peptides for the treatment and suppression of multiple sclerosis. Clin Immunol 144:127-38
Manikwar, Prakash; Büyüktimkin, Barlas; Kiptoo, Paul et al. (2012) I-domain-antigen conjugate (IDAC) for delivering antigenic peptides to APC: synthesis, characterization, and in vivo EAE suppression. Bioconjug Chem 23:509-17

Showing the most recent 10 out of 16 publications