Development of mitochondrially targeted antioxidants for diabetic therapy

Darley-Usmar, Victor M.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Type: High Priority, Short Term Project Award (R56)
• Project #: 1R56DK075865-01
• Application #: 7269123
• Study Section: Myocardial Ischemia and Metabolism Study Section (MIM)
• Program Officer: Jones, Teresa L Z
• Project Start: 2006-09-15
• Project End: 2007-03-31
• Budget Start: 2006-09-15
• Budget End: 2007-03-31
• Support Year: 1
• Fiscal Year: 2006
• Total Cost: $181,875

Institution

• Name: University of Alabama Birmingham
• Department: Pathology
• Type: Schools of Medicine
• DUNS #: 063690705
• City: Birmingham
• State: AL
• Country: United States
• Zip Code: 35294

Publications

Pun, Pamela Boon Li; Logan, Angela; Darley-Usmar, Victor et al. (2014) A mitochondria-targeted mass spectrometry probe to detect glyoxals: implications for diabetes. Free Radic Biol Med 67:437-50

Mitchell, Tanecia; Johnson, Michelle S; Ouyang, Xiaosen et al. (2013) Dysfunctional mitochondrial bioenergetics and oxidative stress in Akita(+/Ins2)-derived ?-cells. Am J Physiol Endocrinol Metab 305:E585-99

Dodson, Matthew; Darley-Usmar, Victor; Zhang, Jianhua (2013) Cellular metabolic and autophagic pathways: traffic control by redox signaling. Free Radic Biol Med 63:207-21

Cummins, Timothy D; Higdon, Ashlee N; Kramer, Philip A et al. (2013) Utilization of fluorescent probes for the quantification and identification of subcellular proteomes and biological processes regulated by lipid peroxidation products. Free Radic Biol Med 59:56-68

Higdon, Ashlee N; Benavides, Gloria A; Chacko, Balu K et al. (2012) Hemin causes mitochondrial dysfunction in endothelial cells through promoting lipid peroxidation: the protective role of autophagy. Am J Physiol Heart Circ Physiol 302:H1394-409

Mitchell, Tanecia; Chacko, Balu K; Darley-Usmar, Victor (2012) Controlling radicals in the powerhouse: development of MitoSOD. Chem Biol 19:1217-8

Hill, Bradford G; Benavides, Gloria A; Lancaster Jr, Jack R et al. (2012) Integration of cellular bioenergetics with mitochondrial quality control and autophagy. Biol Chem 393:1485-1512

Giordano, Samantha; Lee, Jisun; Darley-Usmar, Victor M et al. (2012) Distinct effects of rotenone, 1-methyl-4-phenylpyridinium and 6-hydroxydopamine on cellular bioenergetics and cell death. PLoS One 7:e44610

Mitchell, Tanecia; Darley-Usmar, Victor (2012) Metabolic syndrome and mitochondrial dysfunction: insights from preclinical studies with a mitochondrially targeted antioxidant. Free Radic Biol Med 52:838-40

Schneider, Lonnie; Giordano, Samantha; Zelickson, Blake R et al. (2011) Differentiation of SH-SY5Y cells to a neuronal phenotype changes cellular bioenergetics and the response to oxidative stress. Free Radic Biol Med 51:2007-17