Abstract

The primary objectives of this project will be provide motivation and training in human health effects of electropollution (electric and magnetic fields radiations) and carcinogenic substances using molecular genetics approaches to one undergraduate and two graduate students through different ongoing biomedical projects of Dr. S.K. Dutta. Graduate students, currently working in the MBRS project will continue their studies for 2 to 4 years. Undergraduate students will be expected to continue their studies for 15 to 24 months. Students will be trained in library studies, in collection and analysis of data for presentations of papers in meetings and for publications. The involvement of students in the three currently funded ongoing projects will be in the areas of: (i) Pathogenesis of neuron specific enolase (NSE), which is involved in the glycolytic pathway of neuron cells induced by electropollution. The possible alterations of expression of cloned NSE genes and of chick embryo retina cells by electropollution will also be studied. One graduate student will do thesis work in this project. (ii) The second area relates to construction of DNA probes, containing catabolic genes capable to biodegrade toxic organic chemicals in the environment, for rapid screening of vast numbers of known and unknown soil microorganisms as well as soil DNAs from contaminated sites. One undergraduate student will be involved in these screening studies using DNA probes followed by analytical studies for the expression of genes for biodegradation. (iii) Another funded project (United Nation's Developmental Fund) is in the area of developing DNA diagnostic tools as biomarkers for early detection of haemoglobin pathogenesis and cancer incidence. One graduate student will do thesis work in these studies of detecting B-thalassemic mutations in patients using nonradioactive DNA labeling and PCR (polymerase chain reaction) technology. Two MBRS graduate students are expected to write M.S. and/or Ph.D. theses on their ongoing research areas.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Minority Biomedical Research Support - MBRS (S06)
Project #
5S06GM008016-27S1
Application #
2802337
Study Section
Project Start
Project End
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
27
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
Howard University
Department
Type
DUNS #
056282296
City
Washington
State
DC
Country
United States
Zip Code
20059

  Publications

Faruque, Mezbah U; Chen, Guanjie; Doumatey, Ayo P et al. (2017) Transferability of genome-wide associated loci for asthma in African Americans. J Asthma 54:1-8
Johnston, Henry Richard; Hu, Yi-Juan; Gao, Jingjing et al. (2017) Identifying tagging SNPs for African specific genetic variation from the African Diaspora Genome. Sci Rep 7:46398
Kessler, Michael D; Yerges-Armstrong, Laura; Taub, Margaret A et al. (2016) Challenges and disparities in the application of personalized genomic medicine to populations with African ancestry. Nat Commun 7:12521
Liu, Ching-Ti; Raghavan, Sridharan; Maruthur, Nisa et al. (2016) Trans-ethnic Meta-analysis and Functional Annotation Illuminates the Genetic Architecture of Fasting Glucose and Insulin. Am J Hum Genet 99:56-75
Rand, Kristin A; Rohland, Nadin; Tandon, Arti et al. (2016) Whole-exome sequencing of over 4100 men of African ancestry and prostate cancer risk. Hum Mol Genet 25:371-81
Mathias, Rasika Ann; Taub, Margaret A; Gignoux, Christopher R et al. (2016) A continuum of admixture in the Western Hemisphere revealed by the African Diaspora genome. Nat Commun 7:12522
Ehret, Georg B (see original citation for additional authors) (2016) The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. Nat Genet 48:1171-1184
Kurian, P; Dunston, G; Lindesay, J (2016) How quantum entanglement in DNA synchronizes double-strand breakage by type II restriction endonucleases. J Theor Biol 391:102-12
Ogunjirin, Adebowale E; Fortunak, Joseph M; Brown, LaVerne L et al. (2015) Competition, Selectivity and Efficacy of Analogs of A-84543 for Nicotinic Acetylcholine Receptors with Repositioning of Pyridine Nitrogen. Neurochem Res 40:2131-42
Winchester, Danyelle; Ricks-Santi, Luisel; Mason, Tshela et al. (2015) SPINK1 Promoter Variants Are Associated with Prostate Cancer Predisposing Alterations in Benign Prostatic Hyperplasia Patients. Anticancer Res 35:3811-9

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