The long-range goal of the SCORE Program at Meharry Medical College is to assist in improving the competitive status of the school's research enterprise relative to other health science centers in the United States. The program seeks to create a research environment wherein faculty may improve their research skills and capabilities to efficiently conduct high quality research to disseminate their research through peer-reviewed publications and presentations at national meetings, and to compete for independent extramural research funds. Additionally, the SCORE faculty are dedicated to increasing the number of scientists who are members of minority groups who are currently under-represented in biomedical research by their support of the RISE program. Finally, research projects proposed in the SCORE application will assist the institution in its mission to conduct basic, clinical and applied research with special emphasis on diseases and conditions that disproportionately affect the ethnic minority populations.
The specific aims (measurable objectives) of the current application are to; 1) to increase the number of peer reviewed publication by MBRS investigators from 1.3 to 2.0 papers per year by the end of year-0.3; 2) to maintain the level of faculty presentations at national meetings to above 1 per year; 3) to increase the acquisition of R01 type grants from 10% to 20% of the SCORE investigators by year-04. The current application requests support for 20 regular research projects and 8 pilot projects. Projects are submitted from the School of Medicine departments of Anatomy and Physiology, Biochemistry, Microbiology, Pathology and Pharmacology as well as from the School of Dentistry. Thus the projects focus on a broad spectrum of health related issues including cancer, cardiovascular and pulmonary diseases, signaling and transduction mechanisms, oral health, infectious diseases and neuroscience. Utilizing the increased flexibility and additional resources afforded by the SCORE Program initiative, the program at Meharry Medical College seeks to achieve a more intense research environment, with varied collaborations, to insure that research specific aims are completed, that data are faithfully published and that the pursuit of additional extramural funding is accelerated.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Minority Biomedical Research Support - MBRS (S06)
Project #
3S06GM008037-30S3
Application #
6587582
Study Section
Special Emphasis Panel (ZGM1 (01))
Program Officer
Eckstrand, Irene A
Project Start
1983-09-14
Project End
2003-07-31
Budget Start
2001-08-01
Budget End
2002-07-31
Support Year
30
Fiscal Year
2002
Total Cost
$306,737
Indirect Cost
Name
Meharry Medical College
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
City
Nashville
State
TN
Country
United States
Zip Code
37208
Pulliam, Stephanie R; Pellom Jr, Samuel T; Shanker, Anil et al. (2016) Butyrate regulates the expression of inflammatory and chemotactic cytokines in human acute leukemic cells during apoptosis. Cytokine 84:74-87
Chen, Chau-Kuang; Bruce, Michelle; Tyler, Lauren et al. (2013) Analysis of an environmental exposure health questionnaire in a metropolitan minority population utilizing logistic regression and Support Vector Machines. J Health Care Poor Underserved 24:153-71
Boadi, William Y; Harris, Shalandus; Anderson, Justin B et al. (2013) Lipid peroxides and glutathione status in human progenitor mononuclear (U937) cells following exposure to low doses of nickel and copper. Drug Chem Toxicol 36:155-62
Choudhury, Shahana A; Ladson, Gwinnett; Kabir, Madina S (2012) Evaluation of serotype-specific immunity to Streptococcus pneumoniae in pregnant women and cord blood of infants: impact of race and ethnicity. J Natl Med Assoc 104:251-7
Hall 3rd, Mack; Misra, Smita; Chaudhuri, Minu et al. (2011) Peptide aptamer mimicking RAD51-binding domain of BRCA2 inhibits DNA damage repair and survival in Trypanosoma brucei. Microb Pathog 50:252-62
Kawai, Yumiko; Garduño, Lakisha; Theodore, Melanie et al. (2011) Acetylation-deacetylation of the transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) regulates its transcriptional activity and nucleocytoplasmic localization. J Biol Chem 286:7629-40
Rana, Tanu; Misra, Smita; Mittal, Mukul K et al. (2011) Mechanism of down-regulation of RNA polymerase III-transcribed non-coding RNA genes in macrophages by Leishmania. J Biol Chem 286:6614-26
Farrow, Anitra L; Rana, Tanu; Mittal, Mukul K et al. (2011) Leishmania-induced repression of selected non-coding RNA genes containing B-box element at their promoters in alternatively polarized M2 macrophages. Mol Cell Biochem 350:47-57
Sheng, Liu; Ding, Xinxin; Ferguson, Marcus et al. (2010) Prenatal polycyclic aromatic hydrocarbon exposure leads to behavioral deficits and downregulation of receptor tyrosine kinase, MET. Toxicol Sci 118:625-34
Sharma, Shvetank; Singha, Ujjal K; Chaudhuri, Minu (2010) Role of Tob55 on mitochondrial protein biogenesis in Trypanosoma brucei. Mol Biochem Parasitol 174:89-100

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