Many environmental factors contribute to the continued growth of cancer every year. One group of compounds which have been shown to induce cancer are the polycyclic aromatic hydrocarbons. In order to elucidate the mode of action of these compounds many theories have been developed to relate the polycyclic aromatic hydrocarbons structures to their activity. Computer Modeling has been used extensively to study the polyaromatic hydrocarbons and has lead to a better understanding of the essential molecular features and conformational structures required for the reaction and interaction, necessary in the formation of adducts and subsequent carcinogenic behavior. This work will extend to include other polycyclic aromatic hydrocarbons especially the benzo[c]phenanthrenes- diol epoxides in their interactions with DNA. This will be accomplished using a computer workstation running the programs AGNAS (Algorithm to Generate Nucleic Acid Structures) which was written and designed specifically for this type of analysis. Students will be introduced to the use of the computer for these types of analyses, and will become major contributors to the overall research. Together with this they will become intimately familiar with the current developing technology utilizing computer based imaging and discovery in research and medicine.

Project Start
Project End
Budget Start
Budget End
Support Year
26
Fiscal Year
1996
Total Cost
Indirect Cost
Al-Ghoul, Walid M; Kim, Margarita S; Fazal, Nadeem et al. (2014) Evidence for simvastatin anti-inflammatory actions based on quantitative analyses of NETosis and other inflammation/oxidation markers. Results Immunol 4:14-22
Al-Ghoul, Walid M; Abu-Shaqra, Steven; Park, Byeong Gyu et al. (2010) Melatonin plays a protective role in postburn rodent gut pathophysiology. Int J Biol Sci 6:282-93
Lange, Yvonne; Ye, Jin; Duban, Mark-Eugene et al. (2009) Activation of membrane cholesterol by 63 amphipaths. Biochemistry 48:8505-15
Reyes, Juan F; Stone, Karen; Ramos, Jeanie et al. (2009) Formation of Hirano bodies after inducible expression of a modified form of an actin-cross-linking protein. Eukaryot Cell 8:852-7
Mody, Purvi D; Cannon, Judy L; Bandukwala, Hozefa S et al. (2007) Signaling through CD43 regulates CD4 T-cell trafficking. Blood 110:2974-82
Fazal, Nadeem; Al-Ghoul, Walid M (2007) Thermal injury-plus-sepsis contributes to a substantial deletion of intestinal mesenteric lymph node CD4 T cell via apoptosis. Int J Biol Sci 3:393-401
Fazal, Nadeem; Raziuddin, Syed; Khan, Mehdi et al. (2006) Antigen presenting cells (APCs) from thermally injured and/or septic rats modulate CD4+ T cell responses of naive rat. Biochim Biophys Acta 1762:46-53
Ford, S H; Gallery, J; Nichols, A et al. (1991) High-performance liquid chromatographic analysis of the (cyanoaquo) stereoisomers of several putative vitamin B12 precursors. J Chromatogr 537:235-47
Ford, S H; Nichols, A; Gallery, J M (1991) Separation and study of corrinoid cobalt-ligand isomers by high-performance liquid chromatography. J Chromatogr 536:185-91
Ford, S H; Nichols, A; Shambee, M (1991) The preparation and characterization of the diaquo- forms of several incomplete corrinoids: cobyric acid, cobinamide, and three isomeric cobinic acid pentaamides. J Inorg Biochem 41:235-44