In the proposed biomedical research, the principal investigator and students will attempt to interrupt the dispersal, development and population growth process of the Asian tiger mosquito vector, Aedes albopictus (Skuse) in the Americas. Specifically, the long term or ultimate objective is to prevent the possible transmission of several endemic arboviruses including Dengue and LaCrosse encephalitis virus in the Americas by Aedes albopictus, through the release of sexually sterilized males and the treatment of breeding habitats with larvicidal materials from mucous secretions. These methods should be capable of drastically reducing populations of Ae. albopictus, since there is no therapeutic measure for preventing or treating these human infections. In 1980, the first indigenous transmission of dengue occurred in the United States in thirty-five years and subsequently in 1986. To obtain the objectives the proposed study is divided into five phases (1) oral treatment of adults (laboratory and field cage studies), (2) effects of juveniods on the F1 generation, (3) longevity of the treated males, (4) permanency of male sterility and (5) mucous secretions (extract, test and identify toxic substances in the mucous). Tests for chemosterilant effect will be conducted through oral treatment of the adult stage, Ae. albopictus with three classes of juveniods, benzylphenols (J2419, J2644, J2706), benzodioxoles (J2581, J2693) and a Carbamate (fenoxycarb). Non-hatchability of eggs will be used as a criterion for calculating sterility induced in eggs. The larvicidal effect of mucous secretions will be determined through a series of laboratory tolerance tests with the different larval instars at two or more concentration levels of the secretions. Also, samples of the mucous secretions will be analyzed to separate and determine (through use of HPLC) the target larvicidal material in the mucous.

Project Start
Project End
Budget Start
Budget End
Support Year
22
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Jackson State University
Department
Type
DUNS #
044507085
City
Jackson
State
MS
Country
United States
Zip Code
39217
Beqa, Lule; Fan, Zhen; Singh, Anant Kumar et al. (2011) Gold nano-popcorn attached SWCNT hybrid nanomaterial for targeted diagnosis and photothermal therapy of human breast cancer cells. ACS Appl Mater Interfaces 3:3316-24
Khan, Sadia Afrin; Singh, Anant K; Senapati, Dulal et al. (2011) Targeted highly sensitive detection of multi-drug resistant Salmonella DT104 using gold nanoparticles. Chem Commun (Camb) 47:9444-6
Singh, Anant K; Lu, Wentong; Senapati, Dulal et al. (2011) Long-range nanoparticle surface-energy-transfer ruler for monitoring photothermal therapy response. Small 7:2517-25
Huang, Yong; Zhao, Shulin; Shi, Ming et al. (2010) Chemiluminescent immunoassay of thyroxine enhanced by microchip electrophoresis. Anal Biochem 399:72-7
Wang, Shuguang; Singh, Anant K; Senapati, Dulal et al. (2010) Rapid colorimetric identification and targeted photothermal lysis of Salmonella bacteria by using bioconjugated oval-shaped gold nanoparticles. Chemistry 16:5600-6
Lu, Wentong; Singh, Anant Kumar; Khan, Sadia Afrin et al. (2010) Gold nano-popcorn-based targeted diagnosis, nanotherapy treatment, and in situ monitoring of photothermal therapy response of prostate cancer cells using surface-enhanced Raman spectroscopy. J Am Chem Soc 132:18103-14
Lu, Wentong; Arumugam, Sri Ranjini; Senapati, Dulal et al. (2010) Multifunctional oval-shaped gold-nanoparticle-based selective detection of breast cancer cells using simple colorimetric and highly sensitive two-photon scattering assay. ACS Nano 4:1739-49
Dadiboyena, Sureshbabu; Valente, Edward J; Hamme 2nd, Ashton T (2010) Synthesis of Novel Pyrazoles via [2+3]-Dipolar Cycloaddition Using Alkyne Surrogates. Tetrahedron Lett 51:1341
Stewart, Gernerique; Smith, Keonia; Chornes, Ashley et al. (2010) PHOTOCHEMICAL REACTION OF NITRO-POLYCYCLIC AROMATIC HYDROCARBONS: EFFECT BY SOLVENT AND STRUCTURE. Environ Chem Lett 8:301-306
Zhao, Shulin; Huang, Yong; Shi, Ming et al. (2010) Chemiluminescence resonance energy transfer-based detection for microchip electrophoresis. Anal Chem 82:2036-41

Showing the most recent 10 out of 119 publications