The major long-term goal of our research is to develop in rats a behavioral model for the effects of glucose and fructose on memory storage, reconsolidation, and retrieval. Previously we have shown that the dose-response curves for glucose and fructose on initial memory storage and subsequent reconsolidation follow similar cubic trends. The overall aim of the proposed research is to specify the age-dependent characteristics for this behavioral model. In the proposed experiments we use Fisher-344 rats (3-, 12-, and 24-months old) and we focus on understanding the effects of glucose and fructose on the modulation of recently reactivated or retrieved memories. The general behavioral paradigm we employ is a passive-to-active avoidance negative transfer (discrimination reversal) paradigm and an interpolated reactivation or reminder treatment (re-exposure to the experimental room and footshock). In Experiment 1 we characterize the dose-response function for the effects of fructose on memory in rats across the life span and in Experiment 2 we determine the optimal dose of fructose needed for modulating a recently reactivated memory in these same rat age groups. The purpose of Experiment 3 is to extend the results to rats of various ages in our investigation of the effects of repeated reactivation treatments on memory. In Experiment 4 we investigate the effects of glucose administration on passive avoidance memories of various ages (1 to 21 days) and in Experiment 5 on reactivated memories of various ages (1 to 21 days). The results from our experiments will provide the experimental basis for the behavioral model for the effective use of the important memory modulator glucose, or for any similar modulatory agent on reactivated memories. What is more, the results of our experiments are important because glucose can attenuate impairments in memory in human clinical populations.

Project Start
2000-09-01
Project End
2001-08-31
Budget Start
Budget End
Support Year
29
Fiscal Year
2001
Total Cost
Indirect Cost
Name
New Mexico Highlands University
Department
Type
DUNS #
City
Las Vegas
State
NM
Country
United States
Zip Code
87701
Nesterova, Svitlana V; Wiedenfeld, David J; Nesterov, Vladimir N (2004) 5-Acetyl-2-amino-6-methyl-4-(1-naphthyl)-4H-pyran-3-carbonitrile, methyl 6-amino-5-cyano-2-methyl-4-(1-naphthyl)-4H-pyran-3-carboxylate and tert-butyl 6-amino-5-cyano-2-methyl-4-(1-naphthyl)-4H-pyran-3-carboxylate. Acta Crystallogr C 60:o559-63
Wiedenfeld, David J; Nesterov, Vladimir N; Minton, Mark A et al. (2004) 1-Chloro-3,6-dimethoxy-2,5-dimethylbenzene and 1-chloro-3,6-dimethoxy-2,4-dimethylbenzene. Acta Crystallogr C 60:o536-8
Wiedenfeld, David J; Nesterov, Vladimir N; Minton, Mark A et al. (2003) Bis(2,5-dimethoxy-4-methylphenyl)methane and bis(2,5-dimethoxy-3,4,6-trimethylphenyl)methane. Acta Crystallogr C 59:o700-2
Masthay, Mark B; Sammeth, David M; Helvenston, Merritt C et al. (2002) The laser-induced blue state of bacteriorhodopsin: mechanistic and color regulatory roles of protein-protein interactions, protein-lipid interactions, and metal ions. J Am Chem Soc 124:3418-30
Hayward, W A; Fritz, K R; Greene, E R (2000) Human middle cerebral artery blood velocity during sexual intercourse. J Ultrasound Med 19:871-6
Rodriguez, W A; Horne, C A; Mondragon, A N et al. (1994) Comparable dose-response functions for the effects of glucose and fructose on memory. Behav Neural Biol 61:162-9
Serrano, P A; Beniston, D S; Oxonian, M G et al. (1994) Differential effects of protein kinase inhibitors and activators on memory formation in the 2-day-old chick. Behav Neural Biol 61:60-72
Rodriguez, W A; Phillips, M Y; Rodriguez, S B et al. (1993) Cocaine administration prior to reactivation facilitates later acquisition of an avoidance response in rats. Psychopharmacology (Berl) 112:366-70
Gaensslen, R E; Berka, K M; Herrin Jr, G et al. (1993) Amplification of a genomic sequence in 19th century human bone DNA. Naturwissenschaften 80:80-1
Rodriguez, W A; Rodriguez, S B; Phillips, M Y et al. (1993) Post-reactivation cocaine administration facilitates later acquisition of an avoidance response in rats. Behav Brain Res 59:125-9